8-DemethylsideroxylinCAS# 80621-54-1 |
Quality Control & MSDS
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| Cas No. | 80621-54-1 | SDF | Download SDF |
| PubChem ID | 44258359 | Appearance | Yellow Cryst. |
| Formula | C17H14O5 | M.Wt | 298.3 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6-methylchromen-4-one | ||
| SMILES | CC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC=C(C=C3)O)OC | ||
| Standard InChIKey | VQCXCCMCKDSXMQ-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 8-Demethylsideroxylin is a natural product from Eucalyptus robusta Smith. |
| In vitro | Metabolite Profiling of Eastern Teaberry (Gaultheria procumbens L.) Lipophilic Leaf Extracts with Hyaluronidase and Lipoxygenase Inhibitory Activity.[Pubmed: 28272321 ]Molecules. 2017 Mar 6;22(3). pii: E412.The phytochemical profile and anti-inflammatory activity of Gaultheria procumbens dry lipophilic leaf extracts were evaluated.
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8-Demethylsideroxylin Dilution Calculator
8-Demethylsideroxylin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3523 mL | 16.7616 mL | 33.5233 mL | 67.0466 mL | 83.8082 mL |
| 5 mM | 0.6705 mL | 3.3523 mL | 6.7047 mL | 13.4093 mL | 16.7616 mL |
| 10 mM | 0.3352 mL | 1.6762 mL | 3.3523 mL | 6.7047 mL | 8.3808 mL |
| 50 mM | 0.067 mL | 0.3352 mL | 0.6705 mL | 1.3409 mL | 1.6762 mL |
| 100 mM | 0.0335 mL | 0.1676 mL | 0.3352 mL | 0.6705 mL | 0.8381 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Metabolite Profiling of Eastern Teaberry (Gaultheria procumbens L.) Lipophilic Leaf Extracts with Hyaluronidase and Lipoxygenase Inhibitory Activity.[Pubmed:28272321]
Molecules. 2017 Mar 6;22(3). pii: molecules22030412.
The phytochemical profile and anti-inflammatory activity of Gaultheria procumbens dry lipophilic leaf extracts were evaluated. Forty compounds were identified by GC-MS, representing 86.36% and 81.97% of the petroleum ether (PE) and chloroform (CHE) extracts, respectively, with ursolic acid (28.82%), oleanolic acid (10.11%), methyl benzoate (10.03%), and methyl salicylate (6.88%) dominating in CHE, and methyl benzoate (21.59%), docosane (18.86%), and octacosane (11.72%) prevailing in PE. Three components of CHE were fully identified after flash chromatography isolation and spectroscopic studies as (6S,9R)-vomifoliol (4.35%), 8-demethyl-latifolin (1.13%), and 8-Demethylsideroxylin (2.25%). Hyaluronidase and lipoxygenase inhibitory activity was tested for CHE (IC50 = 282.15 +/- 10.38 mug/mL and 899.97 +/- 31.17 mug/mL, respectively), PE (IC50 = 401.82 +/- 16.12 mug/mL and 738.49 +/- 15.92 mug/mL), and nine of the main constituents versus heparin (IC50 = 366.24 +/- 14.72 mug/mL) and indomethacin (IC50 = 92.60 +/- 3.71 mug/mL) as positive controls. With the best activity/concentration relationships, ursolic and oleanolic acids were recommended as analytical markers for the extracts and plant material. Seasonal variation of both markers following foliar development was investigated by UHPLC-PDA. The highest levels of ursolic (5.36-5.87 mg/g DW of the leaves) and oleanolic (1.14-1.26 mg/g DW) acids were observed between August and October, indicating the optimal season for harvesting.
