Ginkgolic acid C13:0CAS# 20261-38-5 |
Quality Control & MSDS
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| Cas No. | 20261-38-5 | SDF | Download SDF |
| PubChem ID | 161306 | Appearance | White powder |
| Formula | C20H32O3 | M.Wt | 320.47 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Synonyms | Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid | ||
| Solubility | Soluble in methan | ||
| Chemical Name | 2-hydroxy-6-tridecylbenzoic acid | ||
| SMILES | CCCCCCCCCCCCCC1=C(C(=CC=C1)O)C(=O)O | ||
| Standard InChIKey | VEPUCZUJLKAVNM-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-14-17-15-13-16-18(21)19(17)20(22)23/h13,15-16,21H,2-12,14H2,1H3,(H,22,23) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Ginkgolic acid C13:0 has a wide antimicrobial spectrum against E.coli and bacillus subtilis who are bacterias, and penicillium, penicillum purpurogenum, penicillium camemberti and aspergillus niger who are fungis, and the MIC of it against E.coli, bacillus subtilis and penicillium is 7.5, 15, 25 mg/mL seperately. It is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. Ginkgolic acid C13:0 exhibits the high α-glucosidase inhibitory activity; Ginkgolic acid C13:0 represents a new kind of molluscicide agent , it has a pronounced effect on snail mitochondria with gross ultrastructural changes. |
| Targets | Antifection | α-glucosidase |
| In vitro | Purification, identification and the antimicrobial activity of ginkgolic acids in ginkgo seeds.[Reference: WebLink]Journal of Chinese Institute of Food Science and Technology. 2015, 15(3):207-15.Ginkgo seeds were used as materials in this experiment, Ginkgolic acids in ginkgo seeds were extracted by ethanol, and the ethanol extract were further extracted with petroleum ether.
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| In vivo | In vivo assessment of anthelmintic efficacy of ginkgolic acids (C13:0, C15:1) on removal of Pseudodactylogyrus in European eel[Reference: WebLink]Aquaculture, 2009, 297(1-4):38-43.Pseudodactylogyrus is a significant monogenean parasite of the gills of aquacultured European eels, and can cause severe gill pathology.
In this study, effects of the crude extracts, fractions and compounds of exopleura of Ginkgo biloba against Pseudodactylogyrus were investigated under in vivo conditions by bio-assay guided isolation method.
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| Kinase Assay | Potent α-glucosidase inhibitors isolated from Ginkgo biloba leaves.[Pubmed: 26027162]Pak J Biol Sci. 2014 Nov;17(11):1170-8.In vitro α-glucosidase inhibitory activity of Ginkgo biloba leaves was investigated.
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| Animal Research | Effects of the molluscicidal agent GA-C13:0, a natural occurring ginkgolic acid, on snail mitochondria.[Reference: WebLink]Pestic. Biochem. Phys., 2012, 103(2):115-20.Ginkgolic acids (GAs) from the leaves and sarcotesta of Ginkgo biloba L. represent a new kind of molluscicide agent. To date, the mechanism(s) for the observed molluscicidal activity remains largely unknown. Since Ginkgolic acid C13:0(GA-C13:0) has effectively inhibited snail mobility, we examined the effects of the compound on mitochondrial function and gene expression as compared to niclosamide.
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Ginkgolic acid C13:0 Dilution Calculator
Ginkgolic acid C13:0 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1204 mL | 15.6021 mL | 31.2042 mL | 62.4083 mL | 78.0104 mL |
| 5 mM | 0.6241 mL | 3.1204 mL | 6.2408 mL | 12.4817 mL | 15.6021 mL |
| 10 mM | 0.312 mL | 1.5602 mL | 3.1204 mL | 6.2408 mL | 7.801 mL |
| 50 mM | 0.0624 mL | 0.312 mL | 0.6241 mL | 1.2482 mL | 1.5602 mL |
| 100 mM | 0.0312 mL | 0.156 mL | 0.312 mL | 0.6241 mL | 0.7801 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. IC50 value: Inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL); reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL). Target: In vitro: Ginkgolic Acid (C13:0) inhibited not only the growth of S. mutans planktonic cells at minimum inhibitory concentration (MIC) of 4 μg/mL and minimum bactericidal concentration (MBC) of 8 μg/mL but also the acid production and adherence to saliva-coated hydroxyapatite of S. mutans at sub-MIC concentration. In addition, this agent was effective in inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL), and it reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL). Furthermore Ginkgolic Acid (C13:0) disrupted biofilm integrity effectively [1]. In vivo:
References:
[1]. He J, et al. Effects of ginkgoneolic acid on the growth, acidogenicity, adherence, and biofilm of Streptococcus mutans in vitro. Folia Microbiol (Praha). 2013 Mar;58(2):147-53.
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Potent alpha-glucosidase inhibitors isolated from Ginkgo biloba leaves.[Pubmed:26027162]
Pak J Biol Sci. 2014 Nov;17(11):1170-8.
In vitro alpha-glucosidase inhibitory activity of Ginkgo biloba leaves was investigated. The inhibitory activity of methanol extracts from yellow and green leaves was 13.8 and 40.1 mug mL(-1), respectively. Each methanol extract was separated into its respective fraction by solvent-solvent extraction with n-hexane, chloroform, ethyl acetate and n-butanol. The n-hexane fractions (in both methanol extracts from green and yellow leaves) exhibited high alpha-glucosidase inhibitory activity with IC50 values of 13.6 and 13.4 mug mL(-1), respectively. Further fractionation of the n-hexane fractions by silica gel column chromatography gave the most active fraction which was identified as ginkgolic acid (C13:0) and a mixture (C13:0, C15:0, C15: 1, C17:1 and C17:2). Ginkgolic acid (C13:0) exhibited the highest alpha-glucosidase inhibitory activity. This is the first study to successfully isolate ginkgolic acids as alpha-glucosidase inhibitors.
