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4-Methoxycoumarine

CAS# 20280-81-3

4-Methoxycoumarine

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Product Name & Size Price Stock
4-Methoxycoumarine: 5mg $58 In Stock
4-Methoxycoumarine: 10mg Please Inquire In Stock
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Quality Control of 4-Methoxycoumarine

Number of papers citing our products

Chemical structure

4-Methoxycoumarine

3D structure

Chemical Properties of 4-Methoxycoumarine

Cas No. 20280-81-3 SDF Download SDF
PubChem ID 529426 Appearance Powder
Formula C10H8O3 M.Wt 176.17
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-methoxychromen-2-one
SMILES COC1=CC(=O)OC2=CC=CC=C21
Standard InChIKey MLCMXDYMSAZNPC-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H8O3/c1-12-9-6-10(11)13-8-5-3-2-4-7(8)9/h2-6H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 4-Methoxycoumarine

The herbs of Guazuma ulmifolia

Biological Activity of 4-Methoxycoumarine

Description4-Methoxycoumarin has antitumour effects.
In vitro

Cytostatic activity of coumarin metabolites and derivatives in the B16-F10 murine melanoma cell line.[Reference: WebLink]

Melanoma Research, 1999, 9(3):243-248.

Coumarin has antitumour effects in vivo and cytostatic effects in vitro. Its half-life in humans is short (1-1.5 h) and the monohydroxylated biotransformation products have significantly longer half-lives. One or several of these products may thus be responsible for the antitumoral effects.
METHODS AND RESULTS:
We have assayed the in vitro cytostatic activity of five monohydroxylated coumarins (3-, 4-, 6-, 7- and 8-monohydroxycoumarin), their acetates and methyl-ethers. Murine melanoma cells (cell line B16-F10) and murine fibroblasts (B82) were exposed to the test compounds at concentrations between 10 and 160 microg/ml. The cytostatic effects were estimated by reduction of the tetrazolium dye MTT. In the melanoma cells, some of the compounds inhibited growth after exposure for 1 day. In contrast, coumarin inhibited growth to a smaller extent, and only after exposure for 3 days. The most active compounds (3-acetoxycoumarin, 4-methoxycoumarin(4-Methoxycoumarine) and 6-hydroxycoumarin), as well as coumarin, were also assayed in murine fibroblasts.
CONCLUSIONS:
The cytostatic effects of 4-methoxycoumarin(4-Methoxycoumarine) and 6-hydroxycoumarin were less pronounced in fibroblasts than in melanoma cells. Our observations suggest that these compounds may have a greater therapeutic margin.

4-Methoxycoumarine Dilution Calculator

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4-Methoxycoumarine Molarity Calculator

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Preparing Stock Solutions of 4-Methoxycoumarine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.6763 mL 28.3817 mL 56.7634 mL 113.5267 mL 141.9084 mL
5 mM 1.1353 mL 5.6763 mL 11.3527 mL 22.7053 mL 28.3817 mL
10 mM 0.5676 mL 2.8382 mL 5.6763 mL 11.3527 mL 14.1908 mL
50 mM 0.1135 mL 0.5676 mL 1.1353 mL 2.2705 mL 2.8382 mL
100 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.1353 mL 1.4191 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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