Guggulsterone ZBroad spectrum steroid receptor ligand. Antagonizes FXR and displays hypolipidemic activity CAS# 95975-55-6 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 95975-55-6 | SDF | Download SDF |
| PubChem ID | 13873622 | Appearance | Powder |
| Formula | C21H28O2 | M.Wt | 312.5 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Solubility | DMSO : 20.83 mg/mL (66.67 mM; Need ultrasonic) | ||
| Chemical Name | (17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione | ||
| SMILES | CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C | ||
| Standard InChIKey | WDXRGPWQVHZTQJ-AYSLTRBKSA-N | ||
| Standard InChI | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Guggulsterone E&Z is a natural product from Ailanthus grandis, it did not show antimicrobial activity. |
| In vitro | Antimicrobial Activity of Guggulsterone E and Z[Reference: WebLink]Int.J.Curr.Microbiol.App.Sci.,2016,5(10):20-6.Guggulsterone is a main active compound of gum guggul, which has commonly used as ant-inflammatory, hepatoprotective, muscle relaxing, anti-arthritic, hypolipidemic, hypocholestrolemic and anti-obesity.
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| Structure Identification | Pharmacognosy Journal, 2013 , 5 (6) :259-264.Development of HPTLC method for estimation of piperine, guggulsterone E and Z in polyherbal formulation[Reference: WebLink]The different batches of formulation were prepared in laboratory by using authenticated raw material and were subjected to various physical and chemical evaluations. Then the prepared formulation and three commercial formulations were investigated for the qualitative and quantitative estimation of mentioned constituents. |
Guggulsterone Z Dilution Calculator
Guggulsterone Z Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2 mL | 16 mL | 32 mL | 64 mL | 80 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL | 12.8 mL | 16 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL | 6.4 mL | 8 mL |
| 50 mM | 0.064 mL | 0.32 mL | 0.64 mL | 1.28 mL | 1.6 mL |
| 100 mM | 0.032 mL | 0.16 mL | 0.32 mL | 0.64 mL | 0.8 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Development of HPTLC method for estimation of piperine, guggulsterone E and Z in polyherbal formulation
Pharmacognosy Journal, 2013 , 5 (6) :259-264.
The different batches of formulation were prepared in laboratory by using authenticated raw material and were subjected to various physical and chemical evaluations. Then the prepared formulation and three commercial formulations were investigated for the qualitative and quantitative estimation of mentioned constituents. The methanolic extract of all formulations were quantified by using HPTLC studies. Linear regression data for the calibration curves of standards viz. piperine, guggulsterone E and Z showed a good linear relationship over a concentration range of 0.06–0.14 μg/spot, 2.5–17.5 μg/spot, 5–30 μg/spot respectively with the correlation coefficient of 0.99085, 0.99847, 0.9990 respectively and thus exhibits good linearity between concentration and area. The content of guggulsterone E (14.68 %w/w, 13.05 %w/w, 6.36 %w/w, 14.36 %w/w); Guggulsterone Z (31.81 %w/w, 26.95 %w/w, 11.62 %w/w, 23.86 %w/w); and piperine (0.068 %w/w, 0.0150 %w/w, 0.321 %w/w, 0.0375 %w/w) were found in TF, TN, TM, TP prepared and three marketed formulation respectively. Conclusion The proposed HPTLC method was found to be rapid, simple and linear for quantitative estimation of piperine, Guggulsterone E&Z in different formulations and extracts.
