Guggulsterone Z

Broad spectrum steroid receptor ligand. Antagonizes FXR and displays hypolipidemic activity CAS# 95975-55-6

Guggulsterone Z

Catalog No. BCN3793----Order now to get a substantial discount!

Product Name & Size Price Stock
Guggulsterone Z: 5mg Please Inquire In Stock
Guggulsterone Z: 10mg Please Inquire In Stock
Guggulsterone Z: 20mg Please Inquire Please Inquire
Guggulsterone Z: 50mg Please Inquire Please Inquire
Guggulsterone Z: 100mg Please Inquire Please Inquire
Guggulsterone Z: 200mg Please Inquire Please Inquire
Guggulsterone Z: 500mg Please Inquire Please Inquire
Guggulsterone Z: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Guggulsterone Z

Number of papers citing our products

Chemical structure

Guggulsterone Z

3D structure

Chemical Properties of Guggulsterone Z

Cas No. 95975-55-6 SDF Download SDF
PubChem ID 13873622 Appearance Powder
Formula C21H28O2 M.Wt 312.5
Type of Compound Steroids Storage Desiccate at -20°C
Solubility DMSO : 20.83 mg/mL (66.67 mM; Need ultrasonic)
Chemical Name (17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
SMILES CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Standard InChIKey WDXRGPWQVHZTQJ-AYSLTRBKSA-N
Standard InChI InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Guggulsterone Z

The herbs of Ailanthus grandis

Biological Activity of Guggulsterone Z

DescriptionGuggulsterone E&Z is a natural product from Ailanthus grandis, it did not show antimicrobial activity.
In vitro

Antimicrobial Activity of Guggulsterone E and Z[Reference: WebLink]

Int.J.Curr.Microbiol.App.Sci.,2016,5(10):20-6.

Guggulsterone is a main active compound of gum guggul, which has commonly used as ant-inflammatory, hepatoprotective, muscle relaxing, anti-arthritic, hypolipidemic, hypocholestrolemic and anti-obesity.
METHODS AND RESULTS:
In the present study, its antimicrobial activity of Guggulsterone E&Z against five microorganisms i.e. Escherichia coli (Wild), E. Cole (DH5α), Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis were undertaken. Disc diffusion method was used for antimicrobial activity assessment of compound Guggulsterone E&Z . The discs were impregnated with 100 and 200 μg per disc and exposed to culture bed of five test organism i.e. E. coli (Wild), E. coli (DH5α), M. luteus, S. aureus and B. subtilis.
CONCLUSIONS:
After 24 hours of incubation at 37 °C, it was observed that the Guggulsterone E&Z did not show any inhibition zone against the all five test organisms.

Protocol of Guggulsterone Z

Structure Identification
Pharmacognosy Journal, 2013 , 5 (6) :259-264.

Development of HPTLC method for estimation of piperine, guggulsterone E and Z in polyherbal formulation[Reference: WebLink]

The different batches of formulation were prepared in laboratory by using authenticated raw material and were subjected to various physical and chemical evaluations. Then the prepared formulation and three commercial formulations were investigated for the qualitative and quantitative estimation of mentioned constituents.
METHODS AND RESULTS:
The methanolic extract of all formulations were quantified by using HPTLC studies. Linear regression data for the calibration curves of standards viz. piperine, guggulsterone E and Z showed a good linear relationship over a concentration range of 0.06–0.14 μg/spot, 2.5–17.5 μg/spot, 5–30 μg/spot respectively with the correlation coefficient of 0.99085, 0.99847, 0.9990 respectively and thus exhibits good linearity between concentration and area. The content of guggulsterone E (14.68 %w/w, 13.05 %w/w, 6.36 %w/w, 14.36 %w/w); guggulsterone Z (31.81 %w/w, 26.95 %w/w, 11.62 %w/w, 23.86 %w/w); and piperine (0.068 %w/w, 0.0150 %w/w, 0.321 %w/w, 0.0375 %w/w) were found in TF, TN, TM, TP prepared and three marketed formulation respectively.
CONCLUSIONS:
The proposed HPTLC method was found to be rapid, simple and linear for quantitative estimation of piperine, Guggulsterone E&Z in different formulations and extracts.

Guggulsterone Z Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Guggulsterone Z Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Guggulsterone Z

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2 mL 16 mL 32 mL 64 mL 80 mL
5 mM 0.64 mL 3.2 mL 6.4 mL 12.8 mL 16 mL
10 mM 0.32 mL 1.6 mL 3.2 mL 6.4 mL 8 mL
50 mM 0.064 mL 0.32 mL 0.64 mL 1.28 mL 1.6 mL
100 mM 0.032 mL 0.16 mL 0.32 mL 0.64 mL 0.8 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Guggulsterone Z

Development of HPTLC method for estimation of piperine, guggulsterone E and Z in polyherbal formulation

Pharmacognosy Journal, 2013 , 5 (6) :259-264.

The different batches of formulation were prepared in laboratory by using authenticated raw material and were subjected to various physical and chemical evaluations. Then the prepared formulation and three commercial formulations were investigated for the qualitative and quantitative estimation of mentioned constituents. The methanolic extract of all formulations were quantified by using HPTLC studies. Linear regression data for the calibration curves of standards viz. piperine, guggulsterone E and Z showed a good linear relationship over a concentration range of 0.06–0.14 μg/spot, 2.5–17.5 μg/spot, 5–30 μg/spot respectively with the correlation coefficient of 0.99085, 0.99847, 0.9990 respectively and thus exhibits good linearity between concentration and area. The content of guggulsterone E (14.68 %w/w, 13.05 %w/w, 6.36 %w/w, 14.36 %w/w); Guggulsterone Z (31.81 %w/w, 26.95 %w/w, 11.62 %w/w, 23.86 %w/w); and piperine (0.068 %w/w, 0.0150 %w/w, 0.321 %w/w, 0.0375 %w/w) were found in TF, TN, TM, TP prepared and three marketed formulation respectively. Conclusion The proposed HPTLC method was found to be rapid, simple and linear for quantitative estimation of piperine, Guggulsterone E&Z in different formulations and extracts.

Description

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

Keywords:

Guggulsterone Z,95975-55-6,Natural Products,Nuclear Receptors, buy Guggulsterone Z , Guggulsterone Z supplier , purchase Guggulsterone Z , Guggulsterone Z cost , Guggulsterone Z manufacturer , order Guggulsterone Z , high purity Guggulsterone Z

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: