Home >> Research Area >> Jatrorrhizine Hydrochloride

Jatrorrhizine Hydrochloride

CAS# 960383-96-4

Jatrorrhizine Hydrochloride

Catalog No. BCC8193----Order now to get a substantial discount!

Product Name & Size Price Stock
Jatrorrhizine Hydrochloride: 5mg Please Inquire In Stock
Jatrorrhizine Hydrochloride: 10mg Please Inquire In Stock
Jatrorrhizine Hydrochloride: 20mg Please Inquire Please Inquire
Jatrorrhizine Hydrochloride: 50mg Please Inquire Please Inquire
Jatrorrhizine Hydrochloride: 100mg Please Inquire Please Inquire
Jatrorrhizine Hydrochloride: 200mg Please Inquire Please Inquire
Jatrorrhizine Hydrochloride: 500mg Please Inquire Please Inquire
Jatrorrhizine Hydrochloride: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Jatrorrhizine Hydrochloride

Number of papers citing our products

Chemical structure

Jatrorrhizine Hydrochloride

3D structure

Chemical Properties of Jatrorrhizine Hydrochloride

Cas No. 960383-96-4 SDF Download SDF
PubChem ID 21115138 Appearance Powder
Formula C20H21ClNO4 M.Wt 374.8
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol;hydrochloride
SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC.Cl
Standard InChIKey JKMUUZMCSNHBAX-UHFFFAOYSA-O
Standard InChI InChI=1S/C20H19NO4.ClH/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3;/h4-5,8-11H,6-7H2,1-3H3;1H/p+1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Jatrorrhizine Hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Jatrorrhizine Hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Jatrorrhizine Hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6681 mL 13.3404 mL 26.6809 mL 53.3618 mL 66.7022 mL
5 mM 0.5336 mL 2.6681 mL 5.3362 mL 10.6724 mL 13.3404 mL
10 mM 0.2668 mL 1.334 mL 2.6681 mL 5.3362 mL 6.6702 mL
50 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.0672 mL 1.334 mL
100 mM 0.0267 mL 0.1334 mL 0.2668 mL 0.5336 mL 0.667 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Jatrorrhizine Hydrochloride

Jatrorrhizine Hydrochloride Suppresses Proliferation, Migration, and Secretion of Synoviocytes In Vitro and Ameliorates Rat Models of Rheumatoid Arthritis In Vivo.[Pubmed:29783696]

Int J Mol Sci. 2018 May 18;19(5). pii: ijms19051514.

Jatrorrhizine Hydrochloride (JH), an active component isolated from the traditional Chinese herb Coptis chinensis, has been reported to have antimicrobial, antitumor, antihypercholesterolemic, and neuroprotective activities. However, its antirheumatoid arthritis (RA) property remains unknown. In this study, a collagen-induced arthritis (CIA) rat model was used to evaluate the therapeutic effects of JH on RA by using arthritis score, radiological evaluation, and histopathological assessment. The in vitro effects of JH on proliferation, migration, and production of inflammatory mediators in RA-derived fibroblast-like synoviocyte MH7A cells were determined by the EdU incorporation assay, wound healing assay, real-time PCR, and ELISA, respectively. The in vivo studies showed that JH treatment significantly prevented the progression and development of RA in CIA rats through anti-inflammation and suppressing bone destruction. The in vitro studies revealed that JH could effectively attenuate the destructive phenotypes of MH7A cells, including inhibiting proliferation, migration, and production of inflammatory mediators. Further mechanistic analysis demonstrated that JH suppressed tumor necrosis factor alpha (TNFalpha)-stimulated activations of nuclear factor of kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) (ERK and p38) leading to the downregulation of proinflammatory cytokines, which might be beneficial to the antiproliferative and antimigratory activities of FLS cells. Collectively, our results demonstrated that JH has a great potential to be developed into a novel therapeutic agent for treating RA.

Keywords:

Jatrorrhizine Hydrochloride,960383-96-4,Natural Products, buy Jatrorrhizine Hydrochloride , Jatrorrhizine Hydrochloride supplier , purchase Jatrorrhizine Hydrochloride , Jatrorrhizine Hydrochloride cost , Jatrorrhizine Hydrochloride manufacturer , order Jatrorrhizine Hydrochloride , high purity Jatrorrhizine Hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: