Stylopine hydrochlorideCAS# 96087-21-7 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 96087-21-7 | SDF | Download SDF |
| PubChem ID | 131864060 | Appearance | Powder |
| Formula | C19H18ClNO4 | M.Wt | 359.81 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | C1CN2CC3=C(CC2C4=CC5=C(C=C41)OCO5)C=CC6=C3OCO6.Cl | ||
| Standard InChIKey | WZUQSTMUNWBERD-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H17NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,6-7,15H,3-5,8-10H2;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity. |
| In vitro | Stylopine from Chelidonium majus inhibits LPS-induced inflammatory mediators in RAW 264.7 cells.[Pubmed: 15473662]Arch Pharm Res. 2004 Sep;27(9):923-9.Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries.
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Stylopine hydrochloride Dilution Calculator
Stylopine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7792 mL | 13.8962 mL | 27.7924 mL | 55.5849 mL | 69.4811 mL |
| 5 mM | 0.5558 mL | 2.7792 mL | 5.5585 mL | 11.117 mL | 13.8962 mL |
| 10 mM | 0.2779 mL | 1.3896 mL | 2.7792 mL | 5.5585 mL | 6.9481 mL |
| 50 mM | 0.0556 mL | 0.2779 mL | 0.5558 mL | 1.1117 mL | 1.3896 mL |
| 100 mM | 0.0278 mL | 0.139 mL | 0.2779 mL | 0.5558 mL | 0.6948 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Stylopine from Chelidonium majus inhibits LPS-induced inflammatory mediators in RAW 264.7 cells.[Pubmed:15473662]
Arch Pharm Res. 2004 Sep;27(9):923-9.
Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries. Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner. These results suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions. These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus.
