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H-Lys-OH.HCl

CAS# 657-27-2

H-Lys-OH.HCl

Catalog No. BCC2978----Order now to get a substantial discount!

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H-Lys-OH.HCl: 5mg	$6	In Stock
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Quality Control of H-Lys-OH.HCl

Quality Control & MSDS

Purity: >98%

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Chemical structure

3D structure

Chemical Properties of H-Lys-OH.HCl

Cas No.	657-27-2	SDF	Download SDF
PubChem ID	69568	Appearance	Powder
Formula	C6H15ClN2O2	M.Wt	182.7
Type of Compound	N/A	Storage	Desiccate at -20°C
Synonyms	L-Lysine Hydrochloride;L-Lysine Monohydrochloride;Lysine Hydrochloride
Solubility	H2O : ≥ 100 mg/mL (547.50 mM) *"≥" means soluble, but saturation unknown.
Chemical Name	(2S)-2,6-diaminohexanoic acid;hydrochloride
SMILES	C(CCN)CC(C(=O)O)N.Cl
Standard InChIKey	BVHLGVCQOALMSV-JEDNCBNOSA-N
Standard InChI	InChI=1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of H-Lys-OH.HCl

Description

L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.In Vivo:L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhances antioxidant activity. Pre- or post-treatment with L-lysine leads to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement is observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione[1]. L-lysine supplementation almost completely ameliorates vascular calcification. Dietary L-lysine strongly suppresses plasma intact parathyroid hormone in adenine rats and supports a proper bone-vascular axis. The conserved orientation of the femoral apatite in group Lys also evidences the bone-protective effects of L-lysine. Dietary L-lysine elevates plasma alanine, proline, arginine, and homoarginine but not lysine[2]. The dose-dependent delay in gastric emptying observed in rats is confirmed in humans with an increase in halftime of gastric emptying of 4 min/g L-lysine. Moreover, a dose-dependent increase in intestinal fluid accumulation is observed (0.4 mL/min/g L-lysine)[3].

References:
[1]. Al-Malki AL, et al. Suppression of acute pancreatitis by L-lysinein mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [2]. Shimomura A, et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [3]. Baruffol C, et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats. Neurogastroenterol Motil. 2014 Jul;26(7):999-1009.

Protocol

Animal Administration [1][2]
Rats: Nephrocalcinosis in 6-week-old male Wistar rats is induced by continuous injection of rat PTH 1-34 at a dosage of 40 μg/kg per day via an osmotic mini-pump for 50 hours. L-lysine HCl or glycine at a dose of 20 mmol/kg is administered via a gastric tube at 2 hours, 14 hours, 26 hours, and 38 hours after the implantation of the osmotic pump. At the indicated periods, Serum and urinary biochemical parameters, urea nitrogen, albumin, calcium, inorganic phosphate, and magnesium are determined by clinical diagnostic reagents[2]. Mice: Four groups of mice (10 in each group) are assessed. Group I is the control. Animals in groups II-IV are injected intraperitoneally with L-arginine hydrochloride (400 mg/kg body weight [bw]) for 3 days. Group III animals are orally pre-treated with L-lysine(10 mg/kg bw), whereas group IV animals are orally post-treated with L-lysine(10 mg/kg bw). Serum samples are subjected to amylase, lipase, transaminase, and interleukin-6 (IL-6) assays. The pancreas is excised to measure the levels of malondialdehyde, nitric oxide, catalase, superoxide dismutase, reduced glutathione, and glutathione peroxidase[1].

H-Lys-OH.HCl Dilution Calculator

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Preparing Stock Solutions of H-Lys-OH.HCl

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.4735 mL	27.3673 mL	54.7345 mL	109.4691 mL	136.8363 mL
5 mM	1.0947 mL	5.4735 mL	10.9469 mL	21.8938 mL	27.3673 mL
10 mM	0.5473 mL	2.7367 mL	5.4735 mL	10.9469 mL	13.6836 mL
50 mM	0.1095 mL	0.5473 mL	1.0947 mL	2.1894 mL	2.7367 mL
100 mM	0.0547 mL	0.2737 mL	0.5473 mL	1.0947 mL	1.3684 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on H-Lys-OH.HCl

H-Lys-OH·HCl

Description

Keywords:

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H-Lys-OH.HCl

Catalog No. BCC2978----Order now to get a substantial discount!

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Quality Control of H-Lys-OH.HCl

Quality Control & MSDS

Number of papers citing our products

Chemical structure

3D structure

Chemical Properties of H-Lys-OH.HCl

Biological Activity of H-Lys-OH.HCl

Protocol

H-Lys-OH.HCl Dilution Calculator

H-Lys-OH.HCl Molarity Calculator

Preparing Stock Solutions of H-Lys-OH.HCl

Organizitions Citing Our Products recently

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