HG-14-10-04CAS# 1356962-34-9 |
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| Cas No. | 1356962-34-9 | SDF | Download SDF |
| PubChem ID | 56655374 | Appearance | Powder |
| Formula | C29H34ClN7O | M.Wt | 532.08 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 13.3 mg/mL (25.00 mM; Need ultrasonic and warming) | ||
| Chemical Name | 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine | ||
| SMILES | CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)C5=CNC6=CC=CC=C65)Cl)OC | ||
| Standard InChIKey | HRYNCLKDKCPYBF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C29H34ClN7O/c1-35-13-15-37(16-14-35)20-9-11-36(12-10-20)21-7-8-26(27(17-21)38-2)33-29-32-19-24(30)28(34-29)23-18-31-25-6-4-3-5-22(23)25/h3-8,17-20,31H,9-16H2,1-2H3,(H,32,33,34) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
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HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM. IC50 value: 20 nM Target: ALK More information can be found in the following Patent, Example 10 Preparation of substituted pyrimidinamines as ALK kinase inhibitors By Aquila, Brian; Kamhi, Victor; Peng, Bo; Pontz, Timothy; Saeh, Jamal Carlos; Thakur, Kumar; Yang, Bin From U.S. Pat. Appl. Publ. (2012), US 20120028924 A1 20120202.
References:
[1]. U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
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HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM.
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