Karaviloside VIIICAS# 934739-32-9 |
Quality Control & MSDS
Package In Stock
Number of papers citing our products
| Cas No. | 934739-32-9 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C36H58O9 | M.Wt | 634.8 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Karaviloside VIII Dilution Calculator
Karaviloside VIII Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5753 mL | 7.8765 mL | 15.753 mL | 31.506 mL | 39.3825 mL |
| 5 mM | 0.3151 mL | 1.5753 mL | 3.1506 mL | 6.3012 mL | 7.8765 mL |
| 10 mM | 0.1575 mL | 0.7876 mL | 1.5753 mL | 3.1506 mL | 3.9382 mL |
| 50 mM | 0.0315 mL | 0.1575 mL | 0.3151 mL | 0.6301 mL | 0.7876 mL |
| 100 mM | 0.0158 mL | 0.0788 mL | 0.1575 mL | 0.3151 mL | 0.3938 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anti-Inflammatory, Antidiabetic Properties and In Silico Modeling of Cucurbitane-Type Triterpene Glycosides from Fruits of an Indian Cultivar of Momordica charantia L.[Pubmed:33669312]
Molecules. 2021 Feb 16;26(4). pii: molecules26041038.
Diabetes mellitus is a chronic disease and one of the fastest-growing health challenges of the last decades. Studies have shown that chronic low-grade inflammation and activation of the innate immune system are intimately involved in type 2 diabetes pathogenesis. Momordica charantia L. fruits are used in traditional medicine to manage diabetes. Herein, we report the purification of a new 23-O-beta-d-allopyranosyl-5beta,19-epoxycucurbitane-6,24-diene triterpene (charantoside XV, 6) along with 25xi-isopropenylchole-5(6)-ene-3-O-beta-d-glucopyranoside (1), karaviloside VI (2), Karaviloside VIII (3), momordicoside L (4), momordicoside A (5) and kuguaglycoside C (7) from an Indian cultivar of Momordica charantia. At 50 microM compounds, 2-6 differentially affected the expression of pro-inflammatory markers IL-6, TNF-alpha, and iNOS, and mitochondrial marker COX-2. Compounds tested for the inhibition of alpha-amylase and alpha-glucosidase enzymes at 0.87 mM and 1.33 mM, respectively. Compounds showed similar alpha-amylase inhibitory activity than acarbose (0.13 mM) of control (68.0-76.6%). Karaviloside VIII (56.5%) was the most active compound in the alpha-glucosidase assay, followed by karaviloside VI (40.3%), while momordicoside L (23.7%), A (33.5%), and charantoside XV (23.9%) were the least active compounds. To better understand the mode of binding of cucurbitane-triterpenes to these enzymes, in silico docking of the isolated compounds was evaluated with alpha-amylase and alpha-glucosidase.
