Khaephuoside ACAS# 142542-79-8 |
| Cas No. | 142542-79-8 | SDF | File under preparation. |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C20H30O13 | M.Wt | 478.4 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Quality Control & MSDS
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Khaephuoside A Dilution Calculator
Khaephuoside A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0903 mL | 10.4515 mL | 20.903 mL | 41.806 mL | 52.2575 mL |
| 5 mM | 0.4181 mL | 2.0903 mL | 4.1806 mL | 8.3612 mL | 10.4515 mL |
| 10 mM | 0.209 mL | 1.0452 mL | 2.0903 mL | 4.1806 mL | 5.2258 mL |
| 50 mM | 0.0418 mL | 0.209 mL | 0.4181 mL | 0.8361 mL | 1.0452 mL |
| 100 mM | 0.0209 mL | 0.1045 mL | 0.209 mL | 0.4181 mL | 0.5226 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Measurement of Pharmacokinetics and Tissue Distribution of Four Compounds from Nauclea officinalis in Rat Plasma and Tissues through HPLC-MS/MS.[Pubmed:36591325]
J Anal Methods Chem. 2022 Dec 21;2022:5297603.
A rapid, sensitive, selective, and accurate HPLC-MS/MS method was developed and validated for the simultaneous determination of chlorogenic acid, naucleactonin C, Khaephuoside A 3,4-dimethoxyphenyl-1-O-beta-apiofuroseyl(1 ⟶ 2)-beta-D-glucopyranoside in rat plasma and tissues after oral administration of Nauclea officinalis extracts. Chloramphenicol was used as an internal standard (IS). The plasma and tissue samples were extracted by protein precipitation with methanol-ethyl acetate (1 : 1, v/v) including 0.1% (v/v) formic acid. The chromatographic separation was achieved by using an C18 column with gradient elution using mobile phase, which consisted of 0.1% formic acid water (A) and acetonitrile (B) and the flow rate of 0.8 mL/min. Mass spectrometric detection was performed in multiple reaction monitoring (MRM) mode utilizing electrospray ionization (ESI) in negative mode. The developed method exhibited good linearity (determination coefficients, R (2) >/= 0.9849), and the lower limits of quantification were 2, 5, 5, and 25 ng/mL for chlorogenic acid, naucleactonin C, Khaephuoside A, and 3,4-dimethoxyphenyl-1-O-beta-apiofuroseyl(1 ⟶ 2)-beta-D-glucopyranoside. The intraday and interday precisions (relative standard deviation, RSD) were less than 12.65%, while the accuracy was ranged from 86.31 to 114.17%. The recovery rate were 51.85-97.06%, 75.99-106.68%, 77.46-105.35%, and 68.36-103.75% for chlorogenic acid, naucleactonin C, Khaephuoside A, and 3,4-dimethoxyphenyl-1-O-beta-apiofuroseyl(1 ⟶ 2)-beta-D-glucopyranoside the matrix effects were 50.17-116.62%, 86.75-115.99%, 45.79-87.44%, and 51.60-92.34% for chlorogenic acid, naucleactonin C, Khaephuoside A, and 3,4-dimethoxyphenyl-1-O-beta-apiofuroseyl(1 ⟶ 2)-beta-D-glucopyranoside in different matrix. The developed method was successfully applied to a pharmacokinetic study and tissue distribution of four compounds in rats after oral administration of Nauclea officinalis extracts.
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