Lactupicrin

CAS# 65725-11-3

Lactupicrin

Catalog No. BCN0118----Order now to get a substantial discount!

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Lactupicrin: 5mg Please Inquire In Stock
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Quality Control of Lactupicrin

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Chemical structure

Lactupicrin

3D structure

Chemical Properties of Lactupicrin

Cas No. 65725-11-3 SDF Download SDF
PubChem ID 174880 Appearance White powder
Formula C23H22O7 M.Wt 410.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in methan
Chemical Name [(3aR,4S,9aS,9bR)-9-(hydroxymethyl)-6-methyl-3-methylidene-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-(4-hydroxyphenyl)acetate
SMILES CC1=C2C(C3C(C(C1)OC(=O)CC4=CC=C(C=C4)O)C(=C)C(=O)O3)C(=CC2=O)CO
Standard InChIKey UMVSOHBRAQTGQI-XGARDCMYSA-N
Standard InChI InChI=1S/C23H22O7/c1-11-7-17(29-18(27)8-13-3-5-15(25)6-4-13)20-12(2)23(28)30-22(20)21-14(10-24)9-16(26)19(11)21/h3-6,9,17,20-22,24-25H,2,7-8,10H2,1H3/t17-,20+,21-,22-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lactupicrin

1 Lactuca sp. 2 Taraxacum sp.

Biological Activity of Lactupicrin

DescriptionLactupicrin has antimicrobial and anti-cancer effects, it also protect the plant from insect feeding.

Lactupicrin Dilution Calculator

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Lactupicrin Molarity Calculator

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Preparing Stock Solutions of Lactupicrin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4366 mL 12.1832 mL 24.3665 mL 48.7329 mL 60.9162 mL
5 mM 0.4873 mL 2.4366 mL 4.8733 mL 9.7466 mL 12.1832 mL
10 mM 0.2437 mL 1.2183 mL 2.4366 mL 4.8733 mL 6.0916 mL
50 mM 0.0487 mL 0.2437 mL 0.4873 mL 0.9747 mL 1.2183 mL
100 mM 0.0244 mL 0.1218 mL 0.2437 mL 0.4873 mL 0.6092 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lactupicrin

(+)-Germacrene A biosynthesis . The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory[Pubmed:9701594]

Plant Physiol. 1998 Aug;117(4):1381-92.

The leaves and especially the roots of chicory (Cichorium intybus L. ) contain high concentrations of bitter sesquiterpene lactones such as the guianolides Lactupicrin, lactucin, and 8-deoxylactucin. Eudesmanolides and germacranolides are present in smaller amounts. Their postulated biosynthesis through the mevalonate-farnesyl diphosphate-germacradiene pathway has now been confirmed by the isolation of a (+)-germacrene A synthase from chicory roots. This sesquiterpene cyclase was purified 200-fold using a combination of anion-exchange and dye-ligand chromatography. It has a Km value of 6. 6 &mgr;M, an estimated molecular mass of 54 kD, and a (broad) pH optimum around 6.7. Germacrene A, the enzymatic product, proved to be much more stable than reported in literature. Its heat-induced Cope rearrangement into (-)-beta-elemene was utilized to determine its absolute configuration on an enantioselective gas chromatography column. To our knowledge, until now in sesquiterpene biosynthesis, germacrene A has only been reported as an (postulated) enzyme-bound intermediate, which, instead of being released, is subjected to additional cyclization(s) by the same enzyme that generated it from farnesyl diphosphate. However, in chicory germacrene A is released from the sesquiterpene cyclase. Apparently, subsequent oxidations and/or glucosylation of the germacrane skeleton, together with a germacrene cyclase, determine whether guaiane- or eudesmane-type sesquiterpene lactones are produced.

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