MR 16728 hydrochlorideStimulates ACh release CAS# 207403-36-9 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 207403-36-9 | SDF | Download SDF |
| PubChem ID | 378810 | Appearance | Powder |
| Formula | C23H37ClN2O | M.Wt | 393.01 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| Chemical Name | N-[3-(azepan-1-yl)propyl]-2-cyclohexyl-2-phenylacetamide;hydrochloride | ||
| SMILES | C1CCCN(CC1)CCCNC(=O)C(C2CCCCC2)C3=CC=CC=C3.Cl | ||
| Standard InChIKey | QLMQSFIGPVLVAO-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H36N2O.ClH/c26-23(24-16-11-19-25-17-9-1-2-10-18-25)22(20-12-5-3-6-13-20)21-14-7-4-8-15-21;/h3,5-6,12-13,21-22H,1-2,4,7-11,14-19H2,(H,24,26);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | This analog of cetiedil stimulates the release of acetylcholine from synaptosomes. |
MR 16728 hydrochloride Dilution Calculator
MR 16728 hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5445 mL | 12.7223 mL | 25.4446 mL | 50.8893 mL | 63.6116 mL |
| 5 mM | 0.5089 mL | 2.5445 mL | 5.0889 mL | 10.1779 mL | 12.7223 mL |
| 10 mM | 0.2544 mL | 1.2722 mL | 2.5445 mL | 5.0889 mL | 6.3612 mL |
| 50 mM | 0.0509 mL | 0.2544 mL | 0.5089 mL | 1.0178 mL | 1.2722 mL |
| 100 mM | 0.0254 mL | 0.1272 mL | 0.2544 mL | 0.5089 mL | 0.6361 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The effect of MR16728, a cetiedil analogue, on acetylcholine release in Torpedo synaptosomes.[Pubmed:8449232]
Eur J Pharmacol. 1993 Feb 16;231(3):407-13.
MR16728, a cetiedil analogue, enhanced acetylcholine (ACh) release (up to 145% of control) from Torpedo synaptosomes when the release was triggered by a Ca2+ ionophore, A23187 or ionomycin, in the presence of 4 mM Ca2+ in the release medium, but inhibited ACh release induced by KCl depolarization of the presynaptic membrane. MR16728 also inhibited Ca(2+)-ATPase activity measured in purified synaptosomal presynaptic membranes. We studied the stimulation by MR16728 as a function of its concentration; the half-maximal effect was reached at the concentration of 13.5 microM. Moreover the stimulation was more pronounced (up to 300%) when a low concentration of Ca2+ (in the 10-micromolar range) was added to the medium. The enhancement of ACh release was also observed in proteoliposomes having incorporated mediatophore, a presynaptic membrane protein, able to release ACh in a Ca(2+)-dependent manner. Thus, mediatophore is a potential presynaptic target for MR16728.
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