Home >> Research Area >>Natural Products>>Chalcones>> Neosperidin dihydrochalcone

Neosperidin dihydrochalcone

CAS# 20702-77-6

Neosperidin dihydrochalcone

Catalog No. BCN5016----Order now to get a substantial discount!

Product Name & Size Price Stock
Neosperidin dihydrochalcone: 5mg $6 In Stock
Neosperidin dihydrochalcone: 10mg Please Inquire In Stock
Neosperidin dihydrochalcone: 20mg Please Inquire Please Inquire
Neosperidin dihydrochalcone: 50mg Please Inquire Please Inquire
Neosperidin dihydrochalcone: 100mg Please Inquire Please Inquire
Neosperidin dihydrochalcone: 200mg Please Inquire Please Inquire
Neosperidin dihydrochalcone: 500mg Please Inquire Please Inquire
Neosperidin dihydrochalcone: 1000mg Please Inquire Please Inquire

Quality Control of Neosperidin dihydrochalcone

Number of papers citing our products

Chemical structure

Neosperidin dihydrochalcone

3D structure

Chemical Properties of Neosperidin dihydrochalcone

Cas No. 20702-77-6 SDF Download SDF
PubChem ID 30231 Appearance Beige powder
Formula C28H36O15 M.Wt 612.58
Type of Compound Chalcones Storage Desiccate at -20°C
Synonyms Neohesperidin DC; NHDC
Solubility DMSO : ≥ 31 mg/mL (50.61 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
SMILES CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC(=C(C=C4)OC)O)O)CO)O)O)O)O)O
Standard InChIKey ITVGXXMINPYUHD-CUVHLRMHSA-N
Standard InChI InChI=1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Neosperidin dihydrochalcone

The peel of Citrus maxima

Biological Activity of Neosperidin dihydrochalcone

DescriptionNeosperidin dihydrochalcone,a derivative of dihydrochalcone, is a new sweetener, it has a clean sweet taste and a good flavour profile, thus, it has been broadly utilized in food industry.
In vitro

Research progress of Neosperidin dihydrochalcone[Reference: WebLink]

China Condiment, 2008, 33(10):70 -3.

Neosperidin dihydrochalcone(NHDC),a derivative of dihydrochalcone,is a new sweetener.It has a clean sweet taste and a good flavour profile,thus,it has been broadly utilized in food industry.Its properties,synthesis methods,security and its application on food industry are detailed in the paper.Its preparation and its application on food industry are in focus.

Neosperidin dihydrochalcone Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Neosperidin dihydrochalcone Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Neosperidin dihydrochalcone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6324 mL 8.1622 mL 16.3244 mL 32.6488 mL 40.811 mL
5 mM 0.3265 mL 1.6324 mL 3.2649 mL 6.5298 mL 8.1622 mL
10 mM 0.1632 mL 0.8162 mL 1.6324 mL 3.2649 mL 4.0811 mL
50 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.653 mL 0.8162 mL
100 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.3265 mL 0.4081 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Neosperidin dihydrochalcone

Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

In Vitro:Neohesperidin dihydrochalcone shows remarkable radical scavenging activity against stable radical and reactive oxygen species (ROS) in concentration dependent manner. Especially, neohesperidin dihydrochalcone is the most potent inhibitor of H2O2 and HOCl. Neohesperidin dihydrochalcone shows HOCl scavenging activity of 93.5% and H2O2 scavenging property of 73.5%. Neohesperidin dihydrochalcone shows extensive inhibitory effect especially on non-radical ROS H2O2 and HOCl with IC50 values of 205.1, 25.5 μM[1]. Neohesperidin dihydrochalcone is found to be an activator of porcine pancreatic alpha-amylase (PPA) with an IC50 of 389 μM[2].

In Vivo:Neohesperidin dihydrochalcone administration results in significant reduction in activities of two useful markers of liver damage, AST and ALT. The relative levels of NF-κB, IL-6, IL-1β and TNF-α protein in the liver of PQ-treated mice are inhibited by neohesperidin dihydrochalcone[3]. The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone is examined in Wistar Crl:(WI)WU BR rats. No adverse effects are observed at neohesperidin dihydrochalcone levels of up to 5% of the diet, the highest dose level tested, at which the rats consumed about 3.3 g/kg body weight/day[4].

References:
[1]. Choi JM, et al. Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death. Biol Pharm Bull. 2007 Feb;30(2):324-30. [2]. Kashani-Amin E, et al. Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector. FEBS Lett. 2013 Mar 18;587(6):652-8. [3]. Shi Q, et al. Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice. Int Immunopharmacol. 2015 Dec;29(2):722-9. [4]. Waalkens-Berendsen DH, et al. Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats. Regul Toxicol Pharmacol. 2004 Aug;40(1):74-9.

Featured Products
New Products
 

Description

Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

Keywords:

Neosperidin dihydrochalcone,20702-77-6,Neohesperidin DC; NHDC,Natural Products, buy Neosperidin dihydrochalcone , Neosperidin dihydrochalcone supplier , purchase Neosperidin dihydrochalcone , Neosperidin dihydrochalcone cost , Neosperidin dihydrochalcone manufacturer , order Neosperidin dihydrochalcone , high purity Neosperidin dihydrochalcone

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: