Macrophylline

CAS# 27841-97-0

Macrophylline

Catalog No. BCN1987----Order now to get a substantial discount!

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Quality Control of Macrophylline

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Chemical structure

Macrophylline

3D structure

Chemical Properties of Macrophylline

Cas No. 27841-97-0 SDF Download SDF
PubChem ID 5281737 Appearance Powder
Formula C13H21NO3 M.Wt 239.31
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,2R,8R)-2-hydroxy-2,3,5,6,7,8-hexahydro-1H-pyrrolizin-1-yl]methyl (Z)-2-methylbut-2-enoate
SMILES CC=C(C)C(=O)OCC1C2CCCN2CC1O
Standard InChIKey LVZCTOQMFLAKLI-CSZIUDOQSA-N
Standard InChI InChI=1S/C13H21NO3/c1-3-9(2)13(16)17-8-10-11-5-4-6-14(11)7-12(10)15/h3,10-12,15H,4-8H2,1-2H3/b9-3-/t10-,11-,12+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Macrophylline

The herbs of Senecio nemorensis L.

Biological Activity of Macrophylline

Description1. Macrophylline A shows weak inhibitory action on KCl-induced contraction.

Macrophylline Dilution Calculator

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Macrophylline Molarity Calculator

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Preparing Stock Solutions of Macrophylline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1787 mL 20.8934 mL 41.7868 mL 83.5736 mL 104.467 mL
5 mM 0.8357 mL 4.1787 mL 8.3574 mL 16.7147 mL 20.8934 mL
10 mM 0.4179 mL 2.0893 mL 4.1787 mL 8.3574 mL 10.4467 mL
50 mM 0.0836 mL 0.4179 mL 0.8357 mL 1.6715 mL 2.0893 mL
100 mM 0.0418 mL 0.2089 mL 0.4179 mL 0.8357 mL 1.0447 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Macrophylline

Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.[Pubmed:21070010]

J Nat Prod. 2011 Jan 28;74(1):12-5.

An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, Macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 muM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 mug/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.

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