MacrophyllineCAS# 27841-97-0 |
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| Cas No. | 27841-97-0 | SDF | Download SDF |
| PubChem ID | 5281737 | Appearance | Powder |
| Formula | C13H21NO3 | M.Wt | 239.31 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(1S,2R,8R)-2-hydroxy-2,3,5,6,7,8-hexahydro-1H-pyrrolizin-1-yl]methyl (Z)-2-methylbut-2-enoate | ||
| SMILES | CC=C(C)C(=O)OCC1C2CCCN2CC1O | ||
| Standard InChIKey | LVZCTOQMFLAKLI-CSZIUDOQSA-N | ||
| Standard InChI | InChI=1S/C13H21NO3/c1-3-9(2)13(16)17-8-10-11-5-4-6-14(11)7-12(10)15/h3,10-12,15H,4-8H2,1-2H3/b9-3-/t10-,11-,12+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Senecio nemorensis L.
| Description | 1. Macrophylline A shows weak inhibitory action on KCl-induced contraction. |
Macrophylline Dilution Calculator
Macrophylline Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1787 mL | 20.8934 mL | 41.7868 mL | 83.5736 mL | 104.467 mL |
| 5 mM | 0.8357 mL | 4.1787 mL | 8.3574 mL | 16.7147 mL | 20.8934 mL |
| 10 mM | 0.4179 mL | 2.0893 mL | 4.1787 mL | 8.3574 mL | 10.4467 mL |
| 50 mM | 0.0836 mL | 0.4179 mL | 0.8357 mL | 1.6715 mL | 2.0893 mL |
| 100 mM | 0.0418 mL | 0.2089 mL | 0.4179 mL | 0.8357 mL | 1.0447 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.[Pubmed:21070010]
J Nat Prod. 2011 Jan 28;74(1):12-5.
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, Macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 muM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 mug/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.
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