Menisdaurin

CAS# 67765-58-6

Menisdaurin

2D Structure

Catalog No. BCN2552----Order now to get a substantial discount!

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Quality Control of Menisdaurin

3D structure

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Menisdaurin

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Chemical Properties of Menisdaurin

Cas No. 67765-58-6 SDF Download SDF
PubChem ID 5384134 Appearance Powder
Formula C14H19NO7 M.Wt 313.30
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2Z)-2-[4-hydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycyclohex-2-en-1-ylidene]acetonitrile
SMILES C1C(C=CC(=CC#N)C1OC2C(C(C(C(O2)CO)O)O)O)O
Standard InChIKey UTHVFIKQCUKKQW-CLTKARDFSA-N
Standard InChI InChI=1S/C14H19NO7/c15-4-3-7-1-2-8(17)5-9(7)21-14-13(20)12(19)11(18)10(6-16)22-14/h1-3,8-14,16-20H,5-6H2/b7-3-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Menisdaurin

The herbs of Flueggea virosa

Biological Activity of Menisdaurin

DescriptionMenisdaurin is a natural product from Flueggea virosa.

Protocol of Menisdaurin

Structure Identification
J Chromatogr Sci. 2015 May-Jun;53(5):824-9.

Simultaneous quantification of biomarkers bergenin and menisdaurin in the methanol extract of aerial parts of Flueggea virosa by validated HPTLC densitometric method.[Pubmed: 25662964]

A simple, sensitive high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous quantification of biomarker bergenin and Menisdaurin in the methanol extracts of aerial parts of Flueggea virosa (FVME).
METHODS AND RESULTS:
Chromatography was performed on glass-backed silica gel 60F254 HPTLC plates using dichloromethane: methanol as mobile phase. Scanning and quantification was done at UV absorption maxima of 260 nm. The system was found to give compact spot for bergenin and Menisdaurin at Rf = 0.29 ± 0.01 and 0.16 ± 0.01, respectively. The linearity ranges for bergenin and Menisdaurin were found to be the same (100-800 ng/spot) with correlation coefficients (R(2) values) of 0.997 and 0.999, respectively. The limit of detection for bergenin and Menisdaurin was found to be 27 and 36.2 ng/band, respectively, while the limit of quantification was found to be 81 and 108 ng/band, respectively. Intra- and interday precisions (n = 6) for bergenin and Menisdaurin were found to be 1.41-1.71 and 1.65-1.87%, and 1.68-1.89 and 1.75-1.93%, respectively. The percent recoveries were found to be 98.7-99.4 and 99.5-99.9%, respectively, for bergenin and Menisdaurin. The percentage of bergenin and Menisdaurin was found to be 15.25 and 4.22% (w/w), respectively, in FVME.
CONCLUSIONS:
The developed method permitted the simultaneous quantification of bergenin and Menisdaurin and showed good resolution and separation from other constituents of extract; hence, the method can be used to standardize herbal formulations as well as bulk drugs for bergenin and Menisdaurin.

Menisdaurin Dilution Calculator

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Preparing Stock Solutions of Menisdaurin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1918 mL 15.9591 mL 31.9183 mL 63.8366 mL 79.7957 mL
5 mM 0.6384 mL 3.1918 mL 6.3837 mL 12.7673 mL 15.9591 mL
10 mM 0.3192 mL 1.5959 mL 3.1918 mL 6.3837 mL 7.9796 mL
50 mM 0.0638 mL 0.3192 mL 0.6384 mL 1.2767 mL 1.5959 mL
100 mM 0.0319 mL 0.1596 mL 0.3192 mL 0.6384 mL 0.798 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Menisdaurin

Simultaneous quantification of biomarkers bergenin and menisdaurin in the methanol extract of aerial parts of Flueggea virosa by validated HPTLC densitometric method.[Pubmed:25662964]

J Chromatogr Sci. 2015 May-Jun;53(5):824-9.

A simple, sensitive high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous quantification of biomarker bergenin and Menisdaurin in the methanol extracts of aerial parts of Flueggea virosa (FVME). Chromatography was performed on glass-backed silica gel 60F254 HPTLC plates using dichloromethane: methanol as mobile phase. Scanning and quantification was done at UV absorption maxima of 260 nm. The system was found to give compact spot for bergenin and Menisdaurin at Rf = 0.29 +/- 0.01 and 0.16 +/- 0.01, respectively. The linearity ranges for bergenin and Menisdaurin were found to be the same (100-800 ng/spot) with correlation coefficients (R(2) values) of 0.997 and 0.999, respectively. The limit of detection for bergenin and Menisdaurin was found to be 27 and 36.2 ng/band, respectively, while the limit of quantification was found to be 81 and 108 ng/band, respectively. Intra- and interday precisions (n = 6) for bergenin and Menisdaurin were found to be 1.41-1.71 and 1.65-1.87%, and 1.68-1.89 and 1.75-1.93%, respectively. The percent recoveries were found to be 98.7-99.4 and 99.5-99.9%, respectively, for bergenin and Menisdaurin. The percentage of bergenin and Menisdaurin was found to be 15.25 and 4.22% (w/w), respectively, in FVME. The developed method permitted the simultaneous quantification of bergenin and Menisdaurin and showed good resolution and separation from other constituents of extract; hence, the method can be used to standardize herbal formulations as well as bulk drugs for bergenin and Menisdaurin.

Description

Menisdaurin is a cyanogenetic glucoside isolated from Flueggea virosa.

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