2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuranCAS# 67736-22-5 |
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| Cas No. | 67736-22-5 | SDF | Download SDF |
| PubChem ID | 15480861 | Appearance | Powder |
| Formula | C14H10O4 | M.Wt | 242.23 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-(6-hydroxy-1-benzofuran-2-yl)benzene-1,3-diol | ||
| SMILES | C1=CC2=C(C=C1O)OC(=C2)C3=C(C=C(C=C3)O)O | ||
| Standard InChIKey | GYHKMDWFVHCCRA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H10O4/c15-9-3-4-11(12(17)6-9)14-5-8-1-2-10(16)7-13(8)18-14/h1-7,15-17H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The aerial parts of Lespedeza cyrtobotrya.
| Description | 1. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acts as a competitive inhibitor. 2. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities. |
| Targets | Tyrosinase |
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran Dilution Calculator
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1283 mL | 20.6415 mL | 41.2831 mL | 82.5662 mL | 103.2077 mL |
| 5 mM | 0.8257 mL | 4.1283 mL | 8.2566 mL | 16.5132 mL | 20.6415 mL |
| 10 mM | 0.4128 mL | 2.0642 mL | 4.1283 mL | 8.2566 mL | 10.3208 mL |
| 50 mM | 0.0826 mL | 0.4128 mL | 0.8257 mL | 1.6513 mL | 2.0642 mL |
| 100 mM | 0.0413 mL | 0.2064 mL | 0.4128 mL | 0.8257 mL | 1.0321 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The melanin synthesis inhibition and radical scavenging activities of compounds isolated from the aerial part of Lespedeza cyrtobotrya.[Pubmed:20622497]
J Microbiol Biotechnol. 2010 Jun;20(6):988-94.
The EtOAc fraction of Lespedeza cyrtobotrya showed mushroom tyrosinase inhibitory and radical scavenging activity. Four active compounds were isolated based on LH-20 chromatography and HPLC, and the structures were elucidated on the basis of their LC-MS and NMR spectral data, as 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1), eriodictyol-7-O-glucopyranoside (2), haginin A (3), and dalbergioidin (4), respectively. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1) showed mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acted as a competitive inhibitor. Furthermore, 37.3 micronM of compound 1 reduced 50 % of the melanin content on a human melanoma (MNT-1) cells. The radical scavenging activity of 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1), eriodictyol-7-O-glucopyranoside (2), haginin A (3), and dalbergioidin (4) was shown with IC50 values of 11.0, 24.5, 9.0 and 36.5 micronM in an ABTS system and with IC50 values of 42.7, 36.0, 37.7 and 61.7 micronM in a DPPH system, respectively. The mushroom tyrosinase inhibitory activity of EtOAc fraction of Lespedeza cyrtobotrya was contributed by compound 1, 3 and 4, and radical scavenging activity of it was contributed by compound 1-4.
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