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2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

CAS# 67736-22-5

2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

Catalog No. BCN7546----Order now to get a substantial discount!

Product Name & Size Price Stock
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran: 5mg $1098 In Stock
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2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran: 500mg Please Inquire Please Inquire
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Quality Control of 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

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Chemical structure

2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

3D structure

Chemical Properties of 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

Cas No. 67736-22-5 SDF Download SDF
PubChem ID 15480861 Appearance Powder
Formula C14H10O4 M.Wt 242.23
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-(6-hydroxy-1-benzofuran-2-yl)benzene-1,3-diol
SMILES C1=CC2=C(C=C1O)OC(=C2)C3=C(C=C(C=C3)O)O
Standard InChIKey GYHKMDWFVHCCRA-UHFFFAOYSA-N
Standard InChI InChI=1S/C14H10O4/c15-9-3-4-11(12(17)6-9)14-5-8-1-2-10(16)7-13(8)18-14/h1-7,15-17H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

The aerial parts of Lespedeza cyrtobotrya.

Biological Activity of 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

Description1. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acts as a competitive inhibitor. 2. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities.
TargetsTyrosinase

2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran Dilution Calculator

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2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran Molarity Calculator

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Preparing Stock Solutions of 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1283 mL 20.6415 mL 41.2831 mL 82.5662 mL 103.2077 mL
5 mM 0.8257 mL 4.1283 mL 8.2566 mL 16.5132 mL 20.6415 mL
10 mM 0.4128 mL 2.0642 mL 4.1283 mL 8.2566 mL 10.3208 mL
50 mM 0.0826 mL 0.4128 mL 0.8257 mL 1.6513 mL 2.0642 mL
100 mM 0.0413 mL 0.2064 mL 0.4128 mL 0.8257 mL 1.0321 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

The melanin synthesis inhibition and radical scavenging activities of compounds isolated from the aerial part of Lespedeza cyrtobotrya.[Pubmed:20622497]

J Microbiol Biotechnol. 2010 Jun;20(6):988-94.

The EtOAc fraction of Lespedeza cyrtobotrya showed mushroom tyrosinase inhibitory and radical scavenging activity. Four active compounds were isolated based on LH-20 chromatography and HPLC, and the structures were elucidated on the basis of their LC-MS and NMR spectral data, as 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1), eriodictyol-7-O-glucopyranoside (2), haginin A (3), and dalbergioidin (4), respectively. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1) showed mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acted as a competitive inhibitor. Furthermore, 37.3 micronM of compound 1 reduced 50 % of the melanin content on a human melanoma (MNT-1) cells. The radical scavenging activity of 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1), eriodictyol-7-O-glucopyranoside (2), haginin A (3), and dalbergioidin (4) was shown with IC50 values of 11.0, 24.5, 9.0 and 36.5 micronM in an ABTS system and with IC50 values of 42.7, 36.0, 37.7 and 61.7 micronM in a DPPH system, respectively. The mushroom tyrosinase inhibitory activity of EtOAc fraction of Lespedeza cyrtobotrya was contributed by compound 1, 3 and 4, and radical scavenging activity of it was contributed by compound 1-4.

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