NeolitsineCAS# 2466-42-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 2466-42-4 | SDF | Download SDF |
| PubChem ID | 10064778 | Appearance | Powder |
| Formula | C19H17NO4 | M.Wt | 323.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CN1CCC2=CC3=C(C4=C2C1CC5=CC6=C(C=C54)OCO6)OCO3 | ||
| Standard InChIKey | GKEOKAJRKHTDOS-ZDUSSCGKSA-N | ||
| Standard InChI | InChI=1S/C19H17NO4/c1-20-3-2-10-5-16-19(24-9-23-16)18-12-7-15-14(21-8-22-15)6-11(12)4-13(20)17(10)18/h5-7,13H,2-4,8-9H2,1H3/t13-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Neolitsine exhibits EC90 values (concentration at which 90% loss of larval motility is observed) of 6.4 microg/mL. 2. Neolitsine and dicentrine have potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM. |
Neolitsine Dilution Calculator
Neolitsine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0921 mL | 15.4607 mL | 30.9215 mL | 61.8429 mL | 77.3036 mL |
| 5 mM | 0.6184 mL | 3.0921 mL | 6.1843 mL | 12.3686 mL | 15.4607 mL |
| 10 mM | 0.3092 mL | 1.5461 mL | 3.0921 mL | 6.1843 mL | 7.7304 mL |
| 50 mM | 0.0618 mL | 0.3092 mL | 0.6184 mL | 1.2369 mL | 1.5461 mL |
| 100 mM | 0.0309 mL | 0.1546 mL | 0.3092 mL | 0.6184 mL | 0.773 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anthelmintic activity of aporphine alkaloids from Cissampelos capensis.[Pubmed:17309014]
Planta Med. 2007 Mar;73(3):296-7.
Two known aporphine alkaloids, (S)-dicentrine (1) and (S)-Neolitsine (2), have been isolated from the MeOH extract of the aerial parts of Cissampelos capensis (Menispermaceae). The structures of these compounds were elucidated by NMR and MS analysis and comparison to literature data. These compounds were isolated by bioassay-guided fractionation using the Haemonchus contortus larval development assay. Compounds 1 and 2 exhibited EC90 values (concentration at which 90% loss of larval motility is observed) of 6.3 and 6.4 microg/mL, respectively. In an IN VIVO assay, administration of 1 resulted in 67% reduction of worm counts in mice at 25 mg/kg when dosed orally.
Vasorelaxing alkaloids and flavonoids from Cassytha filiformis.[Pubmed:18217715]
J Nat Prod. 2008 Feb;71(2):289-91.
Two new aporphine alkaloids, isofiliformine ( 1) and cassythic acid ( 3), along with 22 known compounds were isolated from whole herb of Cassytha filiformis. Cassythic acid ( 3), cassythine ( 4), Neolitsine ( 7), and dicentrine ( 8) had potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM. Compounds 1, 1,2-methylenedioxy-3,10,11-trimethoxyaporphine ( 2), (-)- O-methylflavinatine ( 10), (-)-salutaridine ( 11), isohamnetin-3- O-beta-glucoside, and isohamnetin-3- O-rutinoside exerted moderate vessel-relaxing activities with IC 50 values from 16.50 to 32.81 microM at the test concentrations.
