Phyllanthusiin CCAS# 142674-52-0 |
Quality Control & MSDS
Package In Stock
Number of papers citing our products
| Cas No. | 142674-52-0 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C40H30O26 | M.Wt | 926.7 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Reference standards. | |||||
Phyllanthusiin C Dilution Calculator
Phyllanthusiin C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.0791 mL | 5.3955 mL | 10.791 mL | 21.582 mL | 26.9774 mL |
| 5 mM | 0.2158 mL | 1.0791 mL | 2.1582 mL | 4.3164 mL | 5.3955 mL |
| 10 mM | 0.1079 mL | 0.5395 mL | 1.0791 mL | 2.1582 mL | 2.6977 mL |
| 50 mM | 0.0216 mL | 0.1079 mL | 0.2158 mL | 0.4316 mL | 0.5395 mL |
| 100 mM | 0.0108 mL | 0.054 mL | 0.1079 mL | 0.2158 mL | 0.2698 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Phyllanthus urinaria increases apoptosis and reduces telomerase activity in human nasopharyngeal carcinoma cells.[Pubmed:19295228]
Forsch Komplementmed. 2009 Feb;16(1):34-40.
BACKGROUND: This study was designed to obtain the chemical fingerprint and to investigate the effect of Phyllanthus urinaria on telomerase activity and apoptotic pathways in the human nasopharyngeal carcinoma cell line (NPC-BM1). MATERIALS AND METHODS: The polyphenol compounds in P. urinaria were investigated by HPLC/MS. Cell viability with the treatment of P. urinaria, gallic acid, ellagic acid, quercetin and cisplatin was detected by MTT assay. TUNEL assay, DNA fragmentation analysis and caspase3 activity were used to confirm apoptotic changes. Telomerase activity was determined using the TRAP assay. RNA isolation and RT-PCR were used to analyze the related genes expression. All experiments on treatments with P. urinaria from 0-3 mg/ml were carried out for 24 h. RESULTS: 5 major compounds including gallic acid, brevifolin carboxylic acid, corilagin, Phyllanthusiin C and ellagic acid were identified as a plant fingerprint by HPLC/MS. With the MTT assay, we demonstrated that P. urinaria, gallic acid and ellagic acid reduce cell viability. The apoptosis features showed DNA fragmentation and increased caspase-3 activity associated with the down-regulation of Bcl-2, but not of Bax, p53, and PCNA (proliferating cell nuclear antigen) in P. urinaria-treated NPC-BM1 cells. Furthermore, treatment of NPC-BM1 cells led to an inhibition of hTERT (human telomerase reverse transcriptase), hTP1 (human telomerase-associated protein 1) and c-myc mRNA expression and to decreased telomerase activity. CONCLUSION: This study suggests that P. urinaria induces the death of NPC-BM1 cells in vitro through the induction of apoptosis and inhibited telomerase activity.
Pelargoniins, new ellagitannins from Pelargonium reniforme.[Pubmed:10975505]
Phytochemistry. 2000 Aug;54(7):701-8.
The range of natural ellagitannins is extended by identification of five new metabolites with 1C4 glucose core, designated as pelargoniins A-D and isocorilagin, and the new phyllanthusiin E methyl ester. They are accompanied in the aerial parts of Pelargonium reniforme by two known structurally related metabolites, corilagin and Phyllanthusiin C, two phenolcarboxylic acids, brevifolincarboxylic acid and phyllanthusiin E, the gallotannin 1-O-galloyl-beta-D-glucopyranose, and the ellagitannins strictinin and isostrictinin having a 4C1-glucose core. The structures of these compounds were established from spectroscopic studies. This is the first example of the co-occurrence of ellagitannins with 4C1 and 1C4 glucopyranose core demonstrated for a member of the Geraniaceae.
