8-Acetyl-7-methoxycoumarinCAS# 89019-07-8 |
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| Cas No. | 89019-07-8 | SDF | Download SDF |
| PubChem ID | 14116752 | Appearance | Powder |
| Formula | C12H10O4 | M.Wt | 218.2 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 8-acetyl-7-methoxychromen-2-one | ||
| SMILES | CC(=O)C1=C(C=CC2=C1OC(=O)C=C2)OC | ||
| Standard InChIKey | OTYBDEHZHXKGBO-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C12H10O4/c1-7(13)11-9(15-2)5-3-8-4-6-10(14)16-12(8)11/h3-6H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Murraya paniculata
| Description | Reference standards. | |||||
8-Acetyl-7-methoxycoumarin Dilution Calculator
8-Acetyl-7-methoxycoumarin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.583 mL | 22.9148 mL | 45.8295 mL | 91.659 mL | 114.5738 mL |
| 5 mM | 0.9166 mL | 4.583 mL | 9.1659 mL | 18.3318 mL | 22.9148 mL |
| 10 mM | 0.4583 mL | 2.2915 mL | 4.583 mL | 9.1659 mL | 11.4574 mL |
| 50 mM | 0.0917 mL | 0.4583 mL | 0.9166 mL | 1.8332 mL | 2.2915 mL |
| 100 mM | 0.0458 mL | 0.2291 mL | 0.4583 mL | 0.9166 mL | 1.1457 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells.[Pubmed:25461322]
Eur J Med Chem. 2015 Jan 27;90:221-31.
Based on the reported anticancer activity of coumarin and pyrazoline derivatives, the present investigation dealt with the design and synthesis of coumarin derivatives bearing diversely substituted pyrazoline moieties 7-10. The non-cyclic isosteres 11a-e of compounds 10a-e were synthesized for comparative reasons. The target compounds were synthesized from 8-Acetyl-7-methoxycoumarin that underwent Claisen-Schmidt condensation with various aldehydes to give the chalcones 6a-e, followed by reaction with hydrazine hydrate, phenyl hydrazine or semicarbazide under the appropriate conditions. Cytotoxicity of the synthesized compounds was evaluated in vitro against liver HepG2 cell line. Compounds were active in the nanomolar range. The most active compounds were investigated for their telomerase inhibition and proapoptotic activities.
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