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S-(-)-Carbidopa

CAS# 28860-95-9

S-(-)-Carbidopa

Catalog No. BCN8453----Order now to get a substantial discount!

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Quality Control of S-(-)-Carbidopa

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Chemical structure

S-(-)-Carbidopa

3D structure

Chemical Properties of S-(-)-Carbidopa

Cas No. 28860-95-9 SDF Download SDF
PubChem ID 34359 Appearance White crystal
Formula C10H14N2O4 M.Wt 226.23
Type of Compound N/A Storage Desiccate at -20°C
Synonyms (S)-(-)-Carbidopa
Solubility DMSO : 10 mg/mL (44.20 mM; Need ultrasonic)
H2O : < 0.1 mg/mL (insoluble)
Chemical Name (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
SMILES CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
Standard InChIKey TZFNLOMSOLWIDK-JTQLQIEISA-N
Standard InChI InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of S-(-)-Carbidopa

DescriptionPeripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.

S-(-)-Carbidopa Dilution Calculator

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S-(-)-Carbidopa Molarity Calculator

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Preparing Stock Solutions of S-(-)-Carbidopa

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4203 mL 22.1014 mL 44.2028 mL 88.4056 mL 110.507 mL
5 mM 0.8841 mL 4.4203 mL 8.8406 mL 17.6811 mL 22.1014 mL
10 mM 0.442 mL 2.2101 mL 4.4203 mL 8.8406 mL 11.0507 mL
50 mM 0.0884 mL 0.442 mL 0.8841 mL 1.7681 mL 2.2101 mL
100 mM 0.0442 mL 0.221 mL 0.442 mL 0.8841 mL 1.1051 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on S-(-)-Carbidopa

Carbidopa is an inhibitor of DOPA decarboxylase, which is used in parkinson disease. Target: DOPA decarboxylase Carbidopa (CD), a competitive inhibitor of aromatic l-amino acid decarboxylase that does not cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation of LD to dopamine [1]. CD premedication improves 11C-5-HTP PET image quality and facilitates detection of NET lesions. Because of the similarity of metabolic pathways, this method could probably be applied to improve PET imaging using other tracers like 18F-DOPA and 11C-DOPA [2]. Carbidopa (100 microM) decreased growth of (but did not kill) SK-N-SH neuroblastoma and A204 rhabdomyosarcoma cells and did not affect proliferation of DU 145 prostate, MCF7 breast, or NCI-H460 large cell lung carcinoma lines. sublethal doses of carbidopa produced additive cytotoxic effects in carcinoid cells in combination with etoposide and cytotoxic synergy in SCLC cells when coincubated with topotecan [3].

References:
[1]. Durso, R., et al., Variable absorption of carbidopa affects both peripheral and central levodopa metabolism. J Clin Pharmacol, 2000. 40(8): p. 854-60. [2]. Orlefors, H., et al., Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography. Eur J Nucl Med Mol Imaging, 2006. 33(1): p. 60-5. [3]. Gilbert, J.A., L.M. Frederick, and M.M. Ames, The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Clin Cancer Res, 2000. 6(11): p. 4365-72.

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Description

Carbidopa is an inhibitor of DOPA decarboxylase, which is used in parkinson disease.

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