Home >> Research Area >>Natural Products>>Phenols>> 3,4-Dihydroxyphenylglycol

3,4-Dihydroxyphenylglycol

CAS# 28822-73-3

3,4-Dihydroxyphenylglycol

Catalog No. BCN5188----Order now to get a substantial discount!

Product Name & Size Price Stock
3,4-Dihydroxyphenylglycol: 5mg Please Inquire In Stock
3,4-Dihydroxyphenylglycol: 10mg Please Inquire In Stock
3,4-Dihydroxyphenylglycol: 20mg Please Inquire Please Inquire
3,4-Dihydroxyphenylglycol: 50mg Please Inquire Please Inquire
3,4-Dihydroxyphenylglycol: 100mg Please Inquire Please Inquire
3,4-Dihydroxyphenylglycol: 200mg Please Inquire Please Inquire
3,4-Dihydroxyphenylglycol: 500mg Please Inquire Please Inquire
3,4-Dihydroxyphenylglycol: 1000mg Please Inquire Please Inquire

Quality Control of 3,4-Dihydroxyphenylglycol

Number of papers citing our products

Chemical structure

3,4-Dihydroxyphenylglycol

3D structure

Chemical Properties of 3,4-Dihydroxyphenylglycol

Cas No. 28822-73-3 SDF Download SDF
PubChem ID 91528 Appearance Powder
Formula C8H10O4 M.Wt 170.2
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-(1,2-dihydroxyethyl)benzene-1,2-diol
SMILES C1=CC(=C(C=C1C(CO)O)O)O
Standard InChIKey MTVWFVDWRVYDOR-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3,4-Dihydroxyphenylglycol

The seeds of Ligustrum lucidum

Biological Activity of 3,4-Dihydroxyphenylglycol

Description1. 3,4-Dihydroxyphenylglycol has antioxidant activity. 2. Plasma 3,4-dihydroxyphenylglycol and 3-methoxy-4-hydroxyphenylglycol are insensitive indicators of alpha 2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers. 3. 3,4-Dihydroxyphenylglycol and hydroxytyrosyl acetate show a strong reactive oxygen species (ROS)-scavenging activity, reducing significantly nitrite levels with a significant decrease on iNOS expression, their phenolic derivatives could play an important role in the anti-inflammatory effect of extra virgin olive oil.
TargetsROS | NOS | COX

3,4-Dihydroxyphenylglycol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

3,4-Dihydroxyphenylglycol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 3,4-Dihydroxyphenylglycol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.8754 mL 29.3772 mL 58.7544 mL 117.5088 mL 146.886 mL
5 mM 1.1751 mL 5.8754 mL 11.7509 mL 23.5018 mL 29.3772 mL
10 mM 0.5875 mL 2.9377 mL 5.8754 mL 11.7509 mL 14.6886 mL
50 mM 0.1175 mL 0.5875 mL 1.1751 mL 2.3502 mL 2.9377 mL
100 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.1751 mL 1.4689 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 3,4-Dihydroxyphenylglycol

A study of the precursors of the natural antioxidant phenol 3,4-dihydroxyphenylglycol in olive oil waste.[Pubmed:23578627]

Food Chem. 2013 Sep 1;140(1-2):154-60.

3,4-Dihydroxyphenylglycol (DHPG) is a potent antioxidant recently found in the free form in olive oil and table olives. DHPG can be recovered from olive oil solid waste by a hydrothermal treatment. It was observed that an increase in the concentration of DHPG occurred when alperujo aqueous extracts were subjected to mild thermal conditions (post-treatment). This fact indicates that certain solubilized compounds or precursors containing DHPG which is released with the post-treatment. In the present study, the precursors of DHPG were identified and characterized after extraction from alperujo using thermal treatment and purification by fractionation on Amberlite(R) XAD16 polyamide and semi-preparative reverse-phase HPLC columns. Their structures were elucidated using HPLC coupled to diode array detector (DAD) and electrospray ionization mass spectrometry (ESI-MS). The results identified three compounds as precursors, and their structures can be attributed to the diastereoisomeric forms of the two beta-hydroxy derivatives of verbascoside and isoverbascoside (beta-hydroxyacteoside and beta-hydroxyisoacteoside), and 2''-hydroxyoleuropein, all of which contain a DHPG moiety, potentially explaining the increases in the concentration of this phenolic compound in olive oil waste.

Pharmacodynamics of norepinephrine reuptake inhibition: Modeling the peripheral and central effects of atomoxetine, duloxetine, and edivoxetine on the biomarker 3,4-dihydroxyphenylglycol in humans.[Pubmed:26011686]

J Clin Pharmacol. 2015 Dec;55(12):1422-31.

Norepinephrine, a neurotransmitter in the autonomic sympathetic nervous system, is deaminated by monoamine oxidase to 3,4-Dihydroxyphenylglycol (DHPG). Inhibition of the NE transporter (NET) using DHPG as a biomarker was evaluated using atomoxetine, duloxetine, and edivoxetine as probe NET inhibitors. Pharmacokinetic and pharmacodynamic data were obtained from healthy subjects (n = 160) from 5 clinical trials. An indirect response model was used to describe the relationship between drug plasma concentration and DHPG concentration in plasma and cerebrospinal fluid (CSF). The baseline plasma DHPG concentration (1130-1240 ng/mL) and Imax (33%-37%) were similar for the 3 drugs. The unbound plasma drug IC50 (IC50U ) based on plasma DHPG was 0.973 nM for duloxetine, 0.136 nM for atomoxetine, and 0.041 nM for edivoxetine. The baseline CSF DHPG concentration (1850-2260 ng/mL) was similar for the 3 drugs, but unlike plasma DHPG, the Imax for DHPG was 38% for duloxetine, 53% for atomoxetine, and75% for edivoxetine. The IC50U based on CSF DHPG was 2.72 nM for atomoxetine, 1.22 nM for duloxetine, and 0.794 nM for edivoxetine. These modeling results provide insights into the pharmacology of NET inhibitors and the use of DHPG as a biomarker.

Naturally occurring hydroxytyrosol derivatives: hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplements.[Pubmed:25526103]

J Agric Food Chem. 2015 Jan 28;63(3):836-46.

This work evaluated the effects of extra virgin olive oil (EVOO) phenols, hydroxytyrosyl acetate (2) and 3,4-Dihydroxyphenylglycol (3), as well as two new acyl derivatives of 3, 4-(1,2-di(butanoyloxy)ethyl)benzene-1,2-diol (7) and 4-(1,2-di(lauroyloxy)ethyl)benzene-1,2-diol (8), on LPS-stimulated murine peritoneal macrophages in comparison with hydroxytyrosol (HTy, 1). Compounds 2, 3, 7, and 8 showed a strong reactive oxygen species (ROS)-scavenging activity, reducing significantly nitrite levels with a significant decrease on iNOS expression [2 (50 muM, 0.44 +/- 0.03; 100 muM, 0.44 +/- 0.01; p < 0.01); 3 (50 muM, 0.37 +/- 0.03; 100 muM, 0.37 +/- 0.01; p < 0.001); 7 (50 muM, 0.45 +/- 0.06; p < 0.01)] . However, only 2 and 3 down-regulated COX-2 expression [2 (50 muM, 0.72 +/- 0.04, p < 0.05; 100 muM, 0.54 +/- 0.06, p < 0.01); 3 (50 muM, 0.56 +/- 0.05, p < 0.05; 100 muM, 0.37 +/- 0.04; p < 0.001)] and prevented IKBalpha degradation [2 (100 muM, 1.63 +/- 0.14, p < 0.01); 3 (100 muM, 1.82 +/- 0.09; p < 0.01)] ; the diacylated compounds 7 and 8 showed worse anti-inflammatory activity than the parent 3. In conclusion, 2 and 3 phenolic derivatives could play an important role in the anti-inflammatory effect of EVOO. The implication of this study for the nutrition and general health of the population rests in the possible use of natural HTy derivatives with better hydrophilic/lipophilic balance, thus improving its pharmacodynamic and pharmacokinetic profiles, as new dietary supplements in foods.

Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are insensitive indicators of alpha 2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers.[Pubmed:1646924]

Life Sci. 1991;49(1):75-84.

The usefulness of the plasma concentrations of two major metabolites of norepinephrine (NE), 3,4-Dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG), as indicators of neuronal NE release was investigated. The potent alpha 2-adrenoceptor agonist, dexmedetomidine, induced only about 15% maximal reductions in the metabolite concentrations, in spite of almost total inhibition of neuronal NE release, as evidenced by 90% reductions in plasma NE concentrations. Similarly, administration of the alpha 2-adrenoceptor antagonist atipamezole was followed by only small increases in plasma DHPG and no change in MHPG levels, in spite of almost six-fold, albeit short-lasting, increases in plasma NE. In contrast, a single dose of the reversible monoamine oxidase type A (MAO-A) inhibitor moclobemide reduced plasma DHPG levels by 78% and MHPG levels by 51%. It is concluded that the plasma concentrations of DHPG and MHPG are largely determined by intraneuronal, MAO-A-dependent metabolism of NE, and do not accurately reflect acute alterations in neuronal NE release. The concentration of NE in venous plasma is clearly a more sensitive indicator of alpha 2-adrenoceptor-mediated regulation of NE release.

Alperujo extract, hydroxytyrosol, and 3,4-dihydroxyphenylglycol are bioavailable and have antioxidant properties in vitamin E-deficient rats--a proteomics and network analysis approach.[Pubmed:22648667]

Mol Nutr Food Res. 2012 Jul;56(7):1137-47.

SCOPE: Olive products are rich in phenolic compounds, which are natural antioxidants in vitro. We tested the in vivo effects of alperujo, an olive production by-product, as well as hydroxytyrosol and 3,4-Dihydroxyphenylglycol (DHPG) isolated from alperujo, on indices and pathways of oxidative and metabolic stress in a vitamin E-deficient rat model. METHODS AND RESULTS: Rats were fed a vitamin E-deficient diet for 10 weeks, followed by this diet supplemented with either 100 mg/kg diet dalpha-tocopherol, alperujo extract, hydroxytyrosol, or 10 mg/kg diet DHPG, for a further 2 weeks. We detected alperujo phenolics in tissues and blood, indicating they are bioavailable. Alperujo extract partially ameliorated elevated plasma levels of thiobarbituric acid reactive substances and also lowered plasma cholesterol levels, whereas hydroxytyrosol increased plasma triglyceride levels. Proteomics and subsequent network analysis revealed that hepatic mitochondrial aldehyde dehydrogenase (ALDH2), of which protein and activity levels were regulated by dalpha-tocopherol and olive phenolics, represents a novel central regulatory protein hub affected by the dietary interventions. CONCLUSION: The in vivo free radical scavenging properties of olive phenolics appear relatively modest in our model. But alternative mechanisms, including regulation of ALDH2, may represent relevant antioxidant mechanisms by which dietary olive phenolics could have beneficial impact on cardiovascular health.

Keywords:

3,4-Dihydroxyphenylglycol,28822-73-3,Natural Products, buy 3,4-Dihydroxyphenylglycol , 3,4-Dihydroxyphenylglycol supplier , purchase 3,4-Dihydroxyphenylglycol , 3,4-Dihydroxyphenylglycol cost , 3,4-Dihydroxyphenylglycol manufacturer , order 3,4-Dihydroxyphenylglycol , high purity 3,4-Dihydroxyphenylglycol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: