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Salicylanilide

Antiviral,antibacterial,antifungal reagent CAS# 87-17-2

Salicylanilide

Catalog No. BCC4712----Order now to get a substantial discount!

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Number of papers citing our products

Chemical structure

Salicylanilide

3D structure

Chemical Properties of Salicylanilide

Cas No. 87-17-2 SDF Download SDF
PubChem ID 6872 Appearance Powder
Formula C13H11NO2 M.Wt 213.23
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 170 mg/mL (797.26 mM; Need ultrasonic and warming)
Chemical Name 2-hydroxy-N-phenylbenzamide
SMILES C1=CC=C(C=C1)NC(=O)C2=CC=CC=C2O
Standard InChIKey WKEDVNSFRWHDNR-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H11NO2/c15-12-9-5-4-8-11(12)13(16)14-10-6-2-1-3-7-10/h1-9,15H,(H,14,16)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Salicylanilide Dilution Calculator

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Salicylanilide Molarity Calculator

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Preparing Stock Solutions of Salicylanilide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.6898 mL 23.4489 mL 46.8977 mL 93.7954 mL 117.2443 mL
5 mM 0.938 mL 4.6898 mL 9.3795 mL 18.7591 mL 23.4489 mL
10 mM 0.469 mL 2.3449 mL 4.6898 mL 9.3795 mL 11.7244 mL
50 mM 0.0938 mL 0.469 mL 0.938 mL 1.8759 mL 2.3449 mL
100 mM 0.0469 mL 0.2345 mL 0.469 mL 0.938 mL 1.1724 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Salicylanilide

Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

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References on Salicylanilide

Synthesis of p-O-Alkyl Salicylanilide Derivatives as Novel EGFR Inhibitors.[Pubmed:26763193]

Drug Dev Res. 2016 Feb;77(1):37-42.

Preclinical Research Epidermal growth factor receptor (EGFR), a validated target for anticancer drugs, plays a critical role in tumorigenesis and tumor development. A series of p-O-alkyl Salicylanilide derivatives were designed and synthesized as novel EGFR inhibitors using a salicylic acid scaffold. A simulated six-membered ring strategy formed through intramolecular hydrogen bonds was employed to mimic the planar quinazoline of the EGFR antagonist, gefitinib. The derived compounds with hydroxyl at the ortho position were more potent than ones with methoxyl group. In particular, compounds 5d and 5b displayed significant EGFR inhibitory (IC50 values = 0.30 and 0.45 muM, respectively) activity as well as potent antiproliferative activity in A431 and HCT-116 tumor cells. These Salicylanilides could be considered as promising lead compounds for developing novel EGFR inhibitors.

Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity.[Pubmed:26879856]

Bioorg Med Chem. 2016 Mar 15;24(6):1322-30.

The research of innovative antimicrobial agents represents a cutting edge topic. Hence, we synthesized and characterised novel Salicylanilide N-monosubstituted carbamates. Twenty compounds were evaluated in vitro against eight bacterial strains and eight fungal species. The lowest minimum inhibitory concentrations (MICs) were found to be 0.49 muM. Genus Staphylococcus, including methicillin-resistant Staphylococcus aureus, and fungus Trichophyton mentagrophytes showed uniformly the highest rate of susceptibility, whilst Gram-negative bacteria and most of the fungi were less susceptible. A wide range of carbamates provided comparable or superior in vitro antimicrobial activity in comparison to established drugs. Interestingly, extended-spectrum beta-lactamase producing strain of Klebsiella pneumoniae was inhibited with MICs starting from 31.25 muM. With respect to Staphylococci, 2-[(4-bromophenyl)carbamoyl]-4-chlorophenyl phenylcarbamate exhibited the lowest MIC values (0.98 muM). 2-[(4-Bromophenyl)carbamoyl]-4-chlorophenyl benzylcarbamate showed the widest spectrum of antifungal action. The results indicate that some Salicylanilide carbamates can be considered to be promising candidates for future investigation.

Description

Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.

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