Senegasaponin B

Name: Senegasaponin B
Brand: BioCrick
SKU: BCX2754

CAS# 167933-49-5

Senegasaponin B 2D chemical structure

2D Structure

Catalog No. BCX2754----Order now to get a substantial discount!

Product Name & Size	Price	Stock
Senegasaponin B: 5mg	Please Inquire	In Stock
Senegasaponin B: 10mg	Please Inquire	In Stock
Senegasaponin B: 20mg	Please Inquire	Please Inquire
Senegasaponin B: 50mg	Please Inquire	Please Inquire
Senegasaponin B: 100mg	Please Inquire	Please Inquire
Senegasaponin B: 200mg	Please Inquire	Please Inquire
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Chemical Properties of Senegasaponin B

Cas No.	167933-49-5	SDF	File under preparation.
PubChem ID	N/A	Appearance	Powder
Formula	C69H102O31	M.Wt	1443.5
Type of Compound	N/A	Storage	Desiccate at -20°C
Solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Quality Control of Senegasaponin B

Quality Control & MSDS

Purity: >98%

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Senegasaponin B Dilution Calculator

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Senegasaponin B Molarity Calculator

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Preparing Stock Solutions of Senegasaponin B

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.6928 mL	3.4638 mL	6.9276 mL	13.8552 mL	17.319 mL
5 mM	0.1386 mL	0.6928 mL	1.3855 mL	2.771 mL	3.4638 mL
10 mM	0.0693 mL	0.3464 mL	0.6928 mL	1.3855 mL	1.7319 mL
50 mM	0.0139 mL	0.0693 mL	0.1386 mL	0.2771 mL	0.3464 mL
100 mM	0.0069 mL	0.0346 mL	0.0693 mL	0.1386 mL	0.1732 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on Senegasaponin B

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega.[Pubmed:21042868]

J Nat Med. 2011 Jan;65(1):149-56.

Senegasaponins [senegin II (1), senegin III (2), senegin IV (3), senegasaponin a (4), and Senegasaponin B (5)] from Polygala senega were re-discovered as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs). Senegasaponins (1-5) showed anti-proliferative activity against HUVECs with IC(50) values in the range 0.6-6.2 muM, and the selective index was 7-100-fold in comparison with those for several cancer cell lines, while the desacyl mixture of senegasaponins (6) and tenuifolin (7) lost anti-proliferative activity, indicating that the 28-O-glycoside moiety and methoxycinnamoyl group were essential for the HUVEC-selective growth inhibition of senegasaponins. Senegin III (2) inhibited the vascular endothelial growth factor (VEGF)-induced in vitro tubular formation of HUVECs and basic fibroblast growth factor (bFGF)-induced in vivo neovascularization in the mouse Matrigel plug assay. Moreover, senegin III (2) suppressed tumor growth in the ddY mice s.c.-inoculated murine sarcoma S180 cells. The analysis of the action mechanism of senegin III (2) suggested that the induction of pigment epithelium-derived factor (PEDF) would contribute to the anti-angiogenic effects of senegasaponins.

Studies of the active substances in herbs used for hair treatment. III. Isolation of hair-regrowth substances from Polygara senega var. latifolia TORR. et GRAY.[Pubmed:10598039]

Biol Pharm Bull. 1999 Nov;22(11):1249-50.

Four active principles, 1, 2, 3 and 4, were isolated from Polygara senega var. latifolia TORR. et GRAY by a combination of partition and column chromatography on silica gel and octadecyl silica gel (ODS), monitored by a hair-regrowth activity assay. Compounds 1, 2, 3 and 4 were identified as senegose A, senegin II, senegin III, and Senegasaponin B by comparison of their spectral data with those of authentic samples.

Product Information

Senegasaponin B (CAS 167933-49-5) is a natural product offered by BioCrick for research applications. Customers can buy or order Senegasaponin B from BioCrick, a supplier and manufacturer of research chemicals, with product specifications, purity, packaging, and pricing information available upon request.