Taxuspine X

CAS# 194782-02-0

Taxuspine X

Catalog No. BCN6936----Order now to get a substantial discount!

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Quality Control of Taxuspine X

Number of papers citing our products

Chemical structure

Taxuspine X

3D structure

Chemical Properties of Taxuspine X

Cas No. 194782-02-0 SDF Download SDF
PubChem ID 124511126 Appearance Powder
Formula C41H50O14 M.Wt 766.83
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1R,2S,3E,5S,7S,8Z,10R,13S)-2,7,9,10,13-pentaacetyloxy-4-(acetyloxymethyl)-8,12,15,15-tetramethyl-5-bicyclo[9.3.1]pentadeca-3,8,11-trienyl] (E)-3-phenylprop-2-enoate
SMILES CC1=C2C(C(=C(C(CC(C(=CC(C(C2(C)C)CC1OC(=O)C)OC(=O)C)COC(=O)C)OC(=O)C=CC3=CC=CC=C3)OC(=O)C)C)OC(=O)C)OC(=O)C
Standard InChIKey FLBNRACKRBUYNP-AHLSXCLRSA-N
Standard InChI InChI=1S/C41H50O14/c1-22-33(50-25(4)43)19-32-36(52-27(6)45)18-31(21-49-24(3)42)35(55-37(48)17-16-30-14-12-11-13-15-30)20-34(51-26(5)44)23(2)39(53-28(7)46)40(54-29(8)47)38(22)41(32,9)10/h11-18,32-36,40H,19-21H2,1-10H3/b17-16+,31-18+,39-23-/t32-,33-,34-,35-,36-,40+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Taxuspine X

The stems of the Japanese yew Taxus cuspidata Sieb. et Zucc.

Biological Activity of Taxuspine X

TargetsP-gp

Taxuspine X Dilution Calculator

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Taxuspine X Molarity Calculator

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Preparing Stock Solutions of Taxuspine X

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3041 mL 6.5204 mL 13.0407 mL 26.0814 mL 32.6018 mL
5 mM 0.2608 mL 1.3041 mL 2.6081 mL 5.2163 mL 6.5204 mL
10 mM 0.1304 mL 0.652 mL 1.3041 mL 2.6081 mL 3.2602 mL
50 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.5216 mL 0.652 mL
100 mM 0.013 mL 0.0652 mL 0.1304 mL 0.2608 mL 0.326 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Taxuspine X

Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis.[Pubmed:10647221]

Phytochemistry. 1999 Dec;52(8):1565-9.

The taxoid chinentaxunine has been isolated from the seeds of Chinese yew Taxus chinensis, and its structure determined on the basis of spectral and chemical methods. In addition, the known taxol C, paclitaxel, 10-deacetyl taxol A, 10-deacetyl-7-epitaxol, 10-deacetyl-10-oxo-7-epi-taxol, taxinine M, taxchinin A, 10-deacetyl taxinine B and Taxuspine X were also isolated and identified from this source.

From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.[Pubmed:24900226]

ACS Med Chem Lett. 2010 Jul 15;1(8):416-21.

Three simplified "non-natural" natural taxanes, related to Taxuspine X, were synthetized and assayed as P-glycoprotein (P-gp) inhibitors. One of them (6) proved to be a very efficient P-gp inhibitor with an IC50 = 7.2 x 10(-6) M. In addition, to rationalize biological data, a pharmacophoric model was built through a ligand-based approach. This model represents the first example of a pharmacophore, which describes interactions of taxanes with P-gp.

Three new bicyclic taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata Sieb. et Zucc.[Pubmed:11261208]

J Asian Nat Prod Res. 1999;2(1):63-70.

Three new bicyclic taxane diterpenes were isolated from the needles of the Japanese yew, Taxus cuspidata Sieb. et Zucc. Their structures were established to be 7,9,10,13-tetraacetoxy-5-cinnamoyloxy-4-hydroxy-methyl-8,12,15,15- tetramethyl-bicyclo[9.3.1] pentadeca-3,8,11-trien-2-ol (2,20-dideacetyl Taxuspine X), 7,9,10,13,20-pentaacetoxy-5-cinnamoyloxy-8,12,15,15-tetramethyl bicyclo[9.3.1] pentadeca-3,8,11-trien-2-ol (2-deacetyl Taxuspine X), and 9,10,13,20-tetraacetoxy-5-cinnamoyloxy-8,12,15,15-tetramethyl-bicyclo[9.3.1] pentadeca-3,8,11-trien-2,7-diol (2,7-dideacetyl Taxuspine X) with the aid of spectroscopic techniques and by comparing with Taxuspine X.

Taxane diterpenoids from seeds of Taxus mairei.[Pubmed:10993234]

Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1344-6.

A new 2(3-->20) abeotaxane, taxumairone A (1), and a new cis-p-coumaroyl myo-inositol have been isolated from the seeds of Taxus mairei in addition to taxin B (2), taxinine A, Taxuspine X, decinnamoyltaxinine E, 5alpha-cinnamoyloxy-9alpha,10beta,13alpha- triacetoxy-taxa-4(20)11-diene and 5alpha-cinnamoyloxy-2alpha,9alpha,10beta,+ ++13alpha-tetraacetoxy-taxa-4(20)11-diene. The structure of 1 was determined by 2D-NMR spectral analysis and chemical correlation with taxin B (2). Compound 1 exhibited potent cytotoxicity against human colon carcinoma cells with an ED50 of 0.1 microg/ml.

Three novel bicyclic 3,8-secotaxane diterpenoids from the needles of the chinese yew, taxus chinensis var. mairei[Pubmed:9834176]

J Nat Prod. 1998 Nov;61(11):1437-40.

Three novel (1-3) and five known bicyclic 3,8-secotaxane diterpenoids were isolated from the needles of the Chinese yew, Taxus chinensis var. mairei. The structures of the new compounds were established, respectively, as (3E,7E)-2alpha,10beta, 13alpha-triacetoxy-5alpha,20-dihydroxy-3,8-secotaxa-3,7, 11-trien-9-one (1), (3E,7E)-2alpha,10beta-diacetoxy-5alpha,13alpha, 20-trihydroxy-3,8-secotaxa-3,7,11-trien-9-one (2), and (3E,8E)-7beta, 9,10beta,13alpha,20-pentaacetoxy-3,8-secotaxa-3,8,11-triene-2alpha, 5alpha-diol (2-deacetyltaxachitriene A) (3), on the basis of spectral analysis. The other five bicyclic taxane diterpenoids were determined as canadensene, 5-deacetyltaxachitriene B, taxachitriene B, taxuspine U, and Taxuspine X by comparison of their physical properties and spectral data with those previously reported.

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