Selinidin

CAS# 19427-82-8

Selinidin

Catalog No. BCN2711----Order now to get a substantial discount!

Product Name & Size Price Stock
Selinidin: 5mg $725 In Stock
Selinidin: 10mg Please Inquire In Stock
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Quality Control of Selinidin

Number of papers citing our products

Chemical structure

Selinidin

3D structure

Chemical Properties of Selinidin

Cas No. 19427-82-8 SDF Download SDF
PubChem ID 668079 Appearance Powder
Formula C19H20O5 M.Wt 328.4
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(9S)-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-h]chromen-9-yl] (Z)-2-methylbut-2-enoate
SMILES CC=C(C)C(=O)OC1CC2=C(C=CC3=C2OC(=O)C=C3)OC1(C)C
Standard InChIKey RRHCDWLSHIIIIT-GHAIFCDISA-N
Standard InChI InChI=1S/C19H20O5/c1-5-11(2)18(21)22-15-10-13-14(24-19(15,3)4)8-6-12-7-9-16(20)23-17(12)13/h5-9,15H,10H2,1-4H3/b11-5-/t15-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Selinidin

The herbs of Peucedanum harry-smithii var. subglabrum

Biological Activity of Selinidin

Description1. Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
TargetsTNF-α | p38MAPK | IkB | IKK

Selinidin Dilution Calculator

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Selinidin Molarity Calculator

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Preparing Stock Solutions of Selinidin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0451 mL 15.2253 mL 30.4507 mL 60.9013 mL 76.1267 mL
5 mM 0.609 mL 3.0451 mL 6.0901 mL 12.1803 mL 15.2253 mL
10 mM 0.3045 mL 1.5225 mL 3.0451 mL 6.0901 mL 7.6127 mL
50 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.609 mL 0.7613 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Selinidin

Selinidin suppresses IgE-mediated mast cell activation by inhibiting multiple steps of Fc epsilonRI signaling.[Pubmed:18310907]

Biol Pharm Bull. 2008 Mar;31(3):442-8.

IgE-mediated mast cell activation is critical for development of allergic inflammation. We have recently found that Selinidin, one of the coumarin derivatives isolated from Angelica keiskei, attenuates mast cell degranulation following engagement of the high-affinity receptor for IgE (Fc epsilonRI) with IgE and antigen. In the present study, we investigated the effects of Selinidin on intracellular signaling and mast cell activation employing bone marrow-derived mast cells. Here, we report that Selinidin attenuates the release of beta-hexosaminidase, synthesis of leukotriene C4, and production of tumor necrosis factor-alpha without affecting IgE-Fc epsilonRI binding. Furthermore, biochemical analyses of the Fc epsilonRI-mediated signaling pathway demonstrated that Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation. These results suggest that this compound suppresses IgE-mediated mast cell activation by inhibiting multiple steps of FcepsilonRI-dependent signaling pathways and would be beneficial for the prevention of allergic inflammation.

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