Tenacigenin B

CAS# 80508-42-5

Tenacigenin B

Catalog No. BCN4342----Order now to get a substantial discount!

Product Name & Size Price Stock
Tenacigenin B: 5mg $903 In Stock
Tenacigenin B: 10mg Please Inquire In Stock
Tenacigenin B: 20mg Please Inquire Please Inquire
Tenacigenin B: 50mg Please Inquire Please Inquire
Tenacigenin B: 100mg Please Inquire Please Inquire
Tenacigenin B: 200mg Please Inquire Please Inquire
Tenacigenin B: 500mg Please Inquire Please Inquire
Tenacigenin B: 1000mg Please Inquire Please Inquire

Quality Control of Tenacigenin B

Number of papers citing our products

Chemical structure

Tenacigenin B

Chemical Properties of Tenacigenin B

Cas No. 80508-42-5 SDF Download SDF
PubChem ID N/A Appearance Powder
Formula C21H32O5 M.Wt 364.5
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Tenacigenin B

The herbs of Marsdenia tenacissima

Biological Activity of Tenacigenin B

TargetsP-gp

Tenacigenin B Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Tenacigenin B Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Tenacigenin B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7435 mL 13.7174 mL 27.4348 mL 54.8697 mL 68.5871 mL
5 mM 0.5487 mL 2.7435 mL 5.487 mL 10.9739 mL 13.7174 mL
10 mM 0.2743 mL 1.3717 mL 2.7435 mL 5.487 mL 6.8587 mL
50 mM 0.0549 mL 0.2743 mL 0.5487 mL 1.0974 mL 1.3717 mL
100 mM 0.0274 mL 0.1372 mL 0.2743 mL 0.5487 mL 0.6859 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Tenacigenin B

The cytotoxic and tyrosine kinase inhibitory properties of C21 steroids and iridoids from the tubers of Alocasia cucullata.[Pubmed:27120176]

J Nat Med. 2016 Jul;70(3):602-9.

Ten steroids and iridoids were isolated from the tubers of Alocasia cucullata (Lour.) G. Don. Among them, alocasgenin A (1) and alocasgenoside B-C (2-3) were new compounds and the aglycone of compound 1, obtained from the acid hydrolysis of 1, was named alocasgenol (1a). Also, for the first time, Tenacigenin B (4), 17beta-tenacigenin-B (5), 3-O-6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1-->4)-beta-D-oleandropyranosyl-tena cigenin C (6), marsdenoside A-B (7-8) and tenacigenoside A-B (9-10) were isolated from the genus Alocasia. The chemical structures were elucidated by the extensive analysis of spectral data and compared with the literature. By evaluation of the cytotoxic and tyrosine kinase inhibition, compounds 1-10, 1a and compound 2 showed significant growth inhibition against two tumour cell lines, MGC-803 and HT-29, while compounds 1, 1a, 3, 6 and 8 presented moderate inhibition. Furthermore, compound 2 had the inhibitory property against the enzyme activity biochemically.

Simultaneous determination of six C21 steroids of Xiao-Ai-Ping injection in rat plasma by LC-MS/MS.[Pubmed:24037806]

Biomed Chromatogr. 2014 Feb;28(2):223-30.

Xiao-Ai-Ping injection (XAPI) is a traditional Chinese medicine that has been widely used to treat cancer. Modern pharmacological studies have demonstrated that C21 steroids are the main active compounds in XAPI. In this study, a sensitive and specific liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated the first time for simultanenous determination of three isomeric pregnane genins (17beta-Tenacigenin B, Tenacigenin B and tenacigenin A) and their corresponding glycosides (tenacigenoside A, tenacissoside F and marsdenoside I) from XAPI in rat plasma. A simple liquid-liquid extraction technique was used after the addition of dexamethasone acetate as internal standard. The chromatography separation of analytes was achieved on an Agilent Zorbax Eclipse XDB-C18 column (3.5 microm, 150 x 3 mm i.d.) using methanol-water as mobile phase in a gradient elution program. Detection was performed in multiple reaction monitoring mode using electrospray ionization in the negative ion mode. The method showed satisfactory linearity over a concentration range 5.00-2000.00 ng/mL for Tenacigenin B, tenacigenin A, marsdenoside I and tenacissoside F (r(2) > 0.99), 10.00-4000.00 ng/mL for 17beta-Tenacigenin B and tenacigenoside A (r(2) > 0.99). Intra- and inter-day precisions (valued as relative standard deviation) were <9.00% and accuracies (as relative error) in the range -6.31 to 7.23%. Finally, this validated method was successfully applied to the pharmacokinetic study of XAPI after intravenous administration to rats.

Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells.[Pubmed:18512984]

J Nat Prod. 2008 Jun;71(6):1049-51.

Tenacissimoside A (1) and 11alpha-O-benzoyl-12beta- O-acetylTenacigenin B (2), two derivatives of Tenacigenin B (3) from the plant Marsdenia tenacissima, reversed multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells. The sensitivity of HepG2/Dox cells to the antitumor drugs doxorubicin, vinblastine, puromycin, and paclitexel was increased by 18-, 10-, 11-, and 6-fold by 20 microg/mL (or 25 microM) of 1 and 16-, 53-, 16-, and 326-fold by 20 microg/mL (or 39 microM) of 2, respectively. A preliminary mechanistic study has suggested that 1 might modulate Pgp-mediated multidrug resistance through directly interacting with the Pgp substrate site.

Keywords:

Tenacigenin B,80508-42-5,Natural Products, buy Tenacigenin B , Tenacigenin B supplier , purchase Tenacigenin B , Tenacigenin B cost , Tenacigenin B manufacturer , order Tenacigenin B , high purity Tenacigenin B

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: