PaeoniflorigenoneCAS# 80454-42-8 |
Quality Control & MSDS
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| Cas No. | 80454-42-8 | SDF | Download SDF |
| PubChem ID | 133475 | Appearance | Powder |
| Formula | C17H18O6 | M.Wt | 318.3 |
| Type of Compound | Monoterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC12CC(=O)C3CC1(OC(C3COC(=O)C4=CC=CC=C4)O2)O | ||
| Standard InChIKey | BANPEMKDTXIFRE-GMKCAIKYSA-N | ||
| Standard InChI | InChI=1S/C17H18O6/c1-16-8-13(18)11-7-17(16,20)23-15(22-16)12(11)9-21-14(19)10-5-3-2-4-6-10/h2-6,11-12,15,20H,7-9H2,1H3/t11-,12+,15-,16+,17-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine. 2. Paeoniflorigenone is cytotoxic and induces apoptosis selectively in the cancer cell lines. 3. Paeoniflorigenone may take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation. 4. Paeoniflorigenone shows anti-inflammatory effects. |
| Targets | NO | Caspase |
Paeoniflorigenone Dilution Calculator
Paeoniflorigenone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1417 mL | 15.7085 mL | 31.4169 mL | 62.8338 mL | 78.5423 mL |
| 5 mM | 0.6283 mL | 3.1417 mL | 6.2834 mL | 12.5668 mL | 15.7085 mL |
| 10 mM | 0.3142 mL | 1.5708 mL | 3.1417 mL | 6.2834 mL | 7.8542 mL |
| 50 mM | 0.0628 mL | 0.3142 mL | 0.6283 mL | 1.2567 mL | 1.5708 mL |
| 100 mM | 0.0314 mL | 0.1571 mL | 0.3142 mL | 0.6283 mL | 0.7854 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa.[Pubmed:20824965]
Pharmazie. 2010 Aug;65(8):624-8.
The roots of two Paeoniaceae family members have long been used as traditional medicines in Korea, China, and Japan. Dry roots of Paeonia lactiflora and dry root bark of P. suffruticosa are used under the traditional names of Paeoniae Radix and Moutan Cortex, respectively. Both Paeoniae Radix and Moutan Cortex have been used as remedies for cardiovascular diseases, for improving blood circulation, or for other uses. It was postulated that both plants may contain common active constituents that contribute to inhibiting blood coagulation and/or platelet aggregation. Eighteen compounds, which have been reported to be present in both plant medicines, were evaluated for their effects on platelet aggregation and blood coagulation. Paeonol (5), paeoniflorin (9), benzoylpaeoniflorin (11), and benzoyloxypaeoniflorin (12) were found to be the major common active constituents and they would collectively contribute to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation. In addition, methylgallate (4), (+)-catechin (7), Paeoniflorigenone (8), galloylpaeoniflorin (13), and daucosterol (16) may also take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation.
Blocking effects of a new component, paeoniflorigenone, in paeony root on neuromuscular junctions of frogs and mice.[Pubmed:6471620]
Jpn J Pharmacol. 1984 May;35(1):61-6.
A new monoterpene, Paeoniflorigenone (PFG) (100-900 micrograms/ml), which was isolated from paeony roots and identified chemically, suppressed both indirectly and directly stimulated muscle twitchings of frog sciatic nerve-sartorius muscle preparation, and it indirectly stimulated muscle twitchings of phrenic nerve-diaphragm muscle preparations. The suppression effect by PFG (300 micrograms/ml) on twitching was not reversed by neostigmine (60 micrograms/ml) and was restored by washing out of PFG. PFG (150 micrograms/ml) depolarized the diaphragm muscle membranes by 10 mV and did not change the electrotonic potentials. PFG (100 micrograms/ml) inhibited weakly acetylcholine (5 micrograms/ml)-induced slow contractions. These results demonstrated that PFG is a depolarizing neuromuscular blocking agent, being similar to succinylcholine, except that PFG did not produce any contraction, but succinylcholine did.
