UvarigrinCAS# 200563-11-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 200563-11-7 | SDF | Download SDF |
| PubChem ID | 78384572 | Appearance | Powder |
| Formula | C37H68O6 | M.Wt | 608.94 |
| Type of Compound | Lipids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[13,15-dihydroxy-15-[5-(1-hydroxytridecyl)oxolan-2-yl]pentadecyl]-2-methyl-2H-furan-5-one | ||
| SMILES | CCCCCCCCCCCCC(C1CCC(O1)C(CC(CCCCCCCCCCCCC2=CC(OC2=O)C)O)O)O | ||
| Standard InChIKey | ADPAPZVYVYEBGS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C37H68O6/c1-3-4-5-6-7-8-13-16-19-22-25-33(39)35-26-27-36(43-35)34(40)29-32(38)24-21-18-15-12-10-9-11-14-17-20-23-31-28-30(2)42-37(31)41/h28,30,32-36,38-40H,3-27,29H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Uvarigrin induces apoptosis in KBv200 cells and KB cells probably through a mitochondria-dependent pathway. 2. Uvarigrin shows cytotoxicity against HCT-8, Bel7402 and A2780 human tumor cell lines at ED50 levels of 0.15, 0.21 and 0.41 microgram/ml, respectively. |
Uvarigrin Dilution Calculator
Uvarigrin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.6422 mL | 8.211 mL | 16.422 mL | 32.844 mL | 41.0549 mL |
| 5 mM | 0.3284 mL | 1.6422 mL | 3.2844 mL | 6.5688 mL | 8.211 mL |
| 10 mM | 0.1642 mL | 0.8211 mL | 1.6422 mL | 3.2844 mL | 4.1055 mL |
| 50 mM | 0.0328 mL | 0.1642 mL | 0.3284 mL | 0.6569 mL | 0.8211 mL |
| 100 mM | 0.0164 mL | 0.0821 mL | 0.1642 mL | 0.3284 mL | 0.4105 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Studies on new cytotoxic annonaceous acetogenins from Uvaria grandiflora and absolute configurations].[Pubmed:11499032]
Yao Xue Xue Bao. 1997 Apr;32(4):286-93.
Two new cytotoxic annonaceous acetogenins, named Uvarigrin(1) and uvarigrandin A(3), were obtained from the roots of Uvaria grandiflora Roxb(Annonaceae). Based on X-ray analysis and Mosher's methodology, the overall absolute configuration of 1 was established as 15S, 17R, 18R, 21R, 22R, 36S. The absolute configuration of 3 was also resolved by Mosher's methodology. The relative configuration of the previously reported uvarigranin (2) was revised. Compound 1 showed cytotoxicity against HCT-8, Bel7402 and A2780 human tumor cell lines at ED50 levels of 0.15, 0.21 and 0.41 microgram.ml-1, respectively.
[Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism].[Pubmed:16758998]
Yao Xue Xue Bao. 2006 Mar;41(3):252-6.
AIM: To study the effect of Uvarigrin on mitochondrial dependent pathway during the apoptosis induced by it in MDR KBv200 cells and their parental sensitive KB cells. METHODS: MTT assay was used to detect the cytotoxic effect of Uvarigrin on KBv200 and KB cells. Annexin V FITC staining identified Uvarigrin-induced apoptosis in KBv200 and KB cells. These cells underwent incubation with DCFH-DA, or DiOC6, followed by flowcytometry for the measurement of reactive oxygen species (ROS) and mitochondrial membrane potential (deltapsim), respectively. The Western blotting analysis was performed on Caspase-9 activation. RESULTS: Uvarigrin inhibited the growth of KBv200 cells and KB cells in vitro. Most of the Uvarigrin-induced cells death was found to be due to apoptosis, as determined by Annexin V FITC staining. During the apoptosis, the level of ROS increased while the level of deltapsim decreased in a time-dependent manner. Uvarigrin triggered Caspase-9 activation. CONCLUSION: Uvarigrin induced apoptosis in KBv200 cells and KB cells probably through a mitochondria-dependent pathway.
