Toll-like Receptor
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.
Products for Toll-like Receptor
- Cat.No. Product Name Information/Activity
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BCC2492
Imiquimod
Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.
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BCC6247
Pam2CSK4
868247-72-7
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BCC6245
Pam3CSK4
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.
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BCC6138
Poly(I:C)
24939-03-5
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BCC4073
Resiquimod (R-848)
Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.
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BCC7460
RWJ 21757
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist.
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BCC5603
C34
TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
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BCC6320
CU CPT 22
CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 µM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 µM.
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BCC6319
CU CPT 4a
1279713-77-7
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BCC5560
Hydroxychloroquine Sulfate
Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling.
