Lysine Methyltransferase

Lysine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the lysine residues on histones, particularly histones H3 and H4. The dysregulation of this methylation is critical in the development of cancer.

Products for Lysine Methyltransferase

Cat.No. Product Name Information/Activity
BCC5624 A 366 A-366 is a potent histone methyltransferase G9a inhibitor with an IC50 of 3.3 nM.
BCC5161 Cyproheptadine hydrochloride Cyproheptadine hydrochloride is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.
BCC2218 EPZ004777 EPZ004777 is a potent, selective DOT1L inhibitor with an IC50 of 0.4 nM.
BCC7432 Ryuvidine 265312-55-8
BCC2430 UNC 0224 UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP
BCC8014 UNC 0642 Potent and selective G9a and GLP inhibitor,UNC0642 is a potent and selective G9a/GLP inhibitor, inhibits G9a/GLP with an IC50 of less than 2.5 nM.
BCC2431 UNC 0646 UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC50 of 6 nM. UNC0646 is also a potent GLP inhibitor (IC50 <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 26 nM.
BCC4552 UNC1999 UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH2/1 with IC50s of <10 nM and 45 nM, repectively.
BCC5625 UNC 2400 1433200-49-7
BCC5626 WDR5 0103 WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM.