Ryuvidine

SETD8 inhibitor; also CDK4 inhibitor CAS# 265312-55-8

Ryuvidine

Catalog No. BCC7432----Order now to get a substantial discount!

Product Name & Size Price Stock
Ryuvidine: 5mg $104 In Stock
Ryuvidine: 10mg Please Inquire In Stock
Ryuvidine: 20mg Please Inquire Please Inquire
Ryuvidine: 50mg Please Inquire Please Inquire
Ryuvidine: 100mg Please Inquire Please Inquire
Ryuvidine: 200mg Please Inquire Please Inquire
Ryuvidine: 500mg Please Inquire Please Inquire
Ryuvidine: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Ryuvidine

Number of papers citing our products

Chemical structure

Ryuvidine

3D structure

Chemical Properties of Ryuvidine

Cas No. 265312-55-8 SDF Download SDF
PubChem ID 481747 Appearance Powder
Formula C15H12N2O2S M.Wt 284.33
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 20 mM in DMSO and to 5 mM in ethanol
Chemical Name 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
SMILES CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C
Standard InChIKey HFPLHASLIOXVGS-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Ryuvidine

DescriptionInhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.

Ryuvidine Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Ryuvidine Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Ryuvidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.517 mL 17.5852 mL 35.1704 mL 70.3408 mL 87.926 mL
5 mM 0.7034 mL 3.517 mL 7.0341 mL 14.0682 mL 17.5852 mL
10 mM 0.3517 mL 1.7585 mL 3.517 mL 7.0341 mL 8.7926 mL
50 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.4068 mL 1.7585 mL
100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.7034 mL 0.8793 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Ryuvidine

A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.[Pubmed:24902048]

PLoS One. 2014 Jun 5;9(6):e98891.

DNA replication is an essential process for cell division and as such it is a process that is directly targeted by several anticancer drugs. CDC7 plays an essential role in the activation of replication origins and has recently been proposed as a novel target for drug discovery. The MCM DNA helicase complex (MCM2-7) is a key target of the CDC7 kinase, and MCM phosphorylation status at specific sites is a reliable biomarker of CDC7 cellular activity. In this work we describe a cell-based assay that utilizes the "In Cell Western Technique" (ICW) to identify compounds that affect cellular CDC7 activity. By screening a library of approved drugs and kinase inhibitors we found several compounds that can affect CDC7-dependent phosphorylation of MCM2 in HeLa cells. Among these, Mitoxantrone, a topoisomerase inhibitor, and Ryuvidine, previously described as a CDK4 inhibitor, cause a reduction in phosphorylated MCM2 levels and a sudden blockade of DNA synthesis that is accompanied by an ATM-dependent checkpoint response. This study sheds light on the previously observed cytotoxity of Ryuvidine, strongly suggesting that it is related to its effect of causing DNA damage.

Small-molecule inhibitors of SETD8 with cellular activity.[Pubmed:25137013]

ACS Chem Biol. 2014 Nov 21;9(11):2471-8.

SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo. SETD8's methyltransferase activity has been implicated in many essential cellular processes including DNA replication, DNA damage response, transcription modulation, and cell cycle regulation. Developing SETD8 inhibitors with cellular activity is a key step toward elucidating the diverse roles of SETD8 via convenient pharmacological perturbation. From the hits of a prior high throughput screen (HTS), SPS8I1-3 (NSC663284, BVT948, and Ryuvidine) were validated as potent SETD8 inhibitors. These compounds contain different structural motifs and inhibit SETD8 via distinct modes. More importantly, these compounds show cellular activity by suppressing the H4K20me1 mark of SETD8 and recapitulate characteristic S/G2/M-phase cell cycle defects as observed for RNAi-mediated SETD8 knockdown. The commonality of SPS8I1-3 against SETD8, together with their distinct structures and mechanisms for SETD8 inhibition, argues for the collective application of these compounds as SETD8 inhibitors.

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.[Pubmed:10743948]

Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines.

Keywords:

Ryuvidine,265312-55-8,Natural Products,Cyclin-Dependent Kinases, buy Ryuvidine , Ryuvidine supplier , purchase Ryuvidine , Ryuvidine cost , Ryuvidine manufacturer , order Ryuvidine , high purity Ryuvidine

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: