6-DeoxyisojacareubinCAS# 26486-92-0 |
Quality Control & MSDS
3D structure
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| Cas No. | 26486-92-0 | SDF | Download SDF |
| PubChem ID | 5464641 | Appearance | Powder |
| Formula | C18H14O5 | M.Wt | 310.30 |
| Type of Compound | Xanthones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 6,11-dihydroxy-3,3-dimethylpyrano[2,3-c]xanthen-7-one | ||
| SMILES | CC1(C=CC2=C3C(=C(C=C2O1)O)C(=O)C4=C(O3)C(=CC=C4)O)C | ||
| Standard InChIKey | XWRLBJDPJRDNKF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H14O5/c1-18(2)7-6-9-13(23-18)8-12(20)14-15(21)10-4-3-5-11(19)16(10)22-17(9)14/h3-8,19-20H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 6-Deoxyisojacareubin has antimicrobial activity. 2. 6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM. 3. 6-Deoxyisojacareubin possesses potency in the inhibition of protein kinase C (PKC). |
| Targets | PKC | Antifection |
6-Deoxyisojacareubin Dilution Calculator
6-Deoxyisojacareubin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2227 mL | 16.1134 mL | 32.2269 mL | 64.4538 mL | 80.5672 mL |
| 5 mM | 0.6445 mL | 3.2227 mL | 6.4454 mL | 12.8908 mL | 16.1134 mL |
| 10 mM | 0.3223 mL | 1.6113 mL | 3.2227 mL | 6.4454 mL | 8.0567 mL |
| 50 mM | 0.0645 mL | 0.3223 mL | 0.6445 mL | 1.2891 mL | 1.6113 mL |
| 100 mM | 0.0322 mL | 0.1611 mL | 0.3223 mL | 0.6445 mL | 0.8057 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A new pyranoxanthone from Garcinia nervosa.[Pubmed:28412841]
Nat Prod Res. 2017 Nov;31(21):2513-2519.
Phytochemical studies on the stem bark of Garcinia nervosa has resulted in the discovery of one new pyranoxanthone derivative, garner xanthone (1) and five other compounds, 1,5-dihydroxyxanthone (2), 6-Deoxyisojacareubin (3), 12b-hydroxy-des-D-garcigerrin A (4) stigmasterol (5), and beta-sitosterol (6). The structures of these compounds were elucidated with the aid of spectroscopic techniques, such as NMR and MS. The crude extracts of the plant were assessed for their antimicrobial activity.
Efficient total synthesis and biological activities of 6-deoxyisojacareubin.[Pubmed:23519477]
Arch Pharm (Weinheim). 2013 Apr;346(4):314-20.
6-Deoxyisojacareubin was directly synthesized in a six-step route with an overall yield of about 20%. In this route, the excellent site selectivity of this Claisen rearrangement-cyclization reaction cascade was achieved by inserting a bulky p-tosyl group into the free 1-OH, and in the last step, some efficient demethylation methods were explored. Furthermore, all synthesized intermediates including 6-Deoxyisojacareubin were evaluated for their inhibitory activity against the QGY-7703 cell line. Of these, compound 1 and 6-Deoxyisojacareubin showed moderate activities with IC50 values of 39.61 and 9.65 microM, respectively, when compared to the positive control 5-fluorouracil with an IC50 value of 11.24 microM. Further investigation using non-radioactive detection of protein kinase C (PKC) suggested that these two compounds possessed potency in the inhibition of PKC.
