6',7'-DihydroxybergamottinCAS# 264234-05-1 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 264234-05-1 | SDF | Download SDF |
| PubChem ID | 12082365 | Appearance | Powder |
| Formula | C21H24O6 | M.Wt | 372.4 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Synonyms | Dihydroxybergamottin | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[(E,6R)-6,7-dihydroxy-3,7-dimethyloct-2-enoxy]furo[3,2-g]chromen-7-one | ||
| SMILES | CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)CCC(C(C)(C)O)O | ||
| Standard InChIKey | IXZUPBUEKFXTSD-INMULRNOSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhibit nifedipine oxidation in a concentration-dependent manner. |
| Targets | P450 (e.g. CYP17) |
| In vitro | Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit.[Pubmed: 26041167 ]Food Chem. 2015 Dec 1;188:77-83.In the current study, we examined the effects of postharvest degreening and storage on phytochemicals in Rio Red grapefruit. |
| Kinase Assay | Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells.[Pubmed: 23146034]J Pharm Pharmacol. 2012 Dec;64(12):1715-21.We previously established HepG2-GS-3A4, a cell line from hepatoblastoma with overexpression of human CYP3A4 and glutamine synthetase (GS). We further reported that these cells can be applied for screening inhibitors of CYP3A4 in vitro. |
6',7'-Dihydroxybergamottin Dilution Calculator
6',7'-Dihydroxybergamottin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6853 mL | 13.4264 mL | 26.8528 mL | 53.7057 mL | 67.1321 mL |
| 5 mM | 0.5371 mL | 2.6853 mL | 5.3706 mL | 10.7411 mL | 13.4264 mL |
| 10 mM | 0.2685 mL | 1.3426 mL | 2.6853 mL | 5.3706 mL | 6.7132 mL |
| 50 mM | 0.0537 mL | 0.2685 mL | 0.5371 mL | 1.0741 mL | 1.3426 mL |
| 100 mM | 0.0269 mL | 0.1343 mL | 0.2685 mL | 0.5371 mL | 0.6713 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit.[Pubmed:26041167]
Food Chem. 2015 Dec 1;188:77-83.
In the current study, we examined the effects of postharvest degreening and storage on phytochemicals in Rio Red grapefruit. Grapefruits were degreened with 3.5 mul/l of ethylene at 21 degrees C and 80% relative humidity for 72 h, while non-degreened fruits were used as the control. Furthermore, the grapefruits were stored at 11 degrees C for 3 weeks and then at 21 degrees C for 2 weeks. Degreening improved the peel colour of the grapefruit without affecting total soluble solids or acidity of the juice. Degreened fruits had significantly more ascorbic acid after 35 days of storage. Degreening had no significant effect on the levels of carotenoids, limonoids and flavonoids as compared to the non-degreened fruits, after 35 days of storage. However, after 7 days, degreened fruits had more limonin and flavonoids and less furocoumarin, namely 6',7'-dihydroxybergamottin. Overall, ethylene treatment had a significant effect on the phytochemical contents of Rio Red grapefruit, especially after 7 days of storage.
