6',7'-DihydroxybergamottinCAS# 264234-05-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 264234-05-1 | SDF | Download SDF |
PubChem ID | 12082365 | Appearance | Powder |
Formula | C21H24O6 | M.Wt | 372.4 |
Type of Compound | Coumarins | Storage | Desiccate at -20°C |
Synonyms | Dihydroxybergamottin | ||
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 4-[(E,6R)-6,7-dihydroxy-3,7-dimethyloct-2-enoxy]furo[3,2-g]chromen-7-one | ||
SMILES | CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)CCC(C(C)(C)O)O | ||
Standard InChIKey | IXZUPBUEKFXTSD-INMULRNOSA-N | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhibit nifedipine oxidation in a concentration-dependent manner. |
Targets | P450 (e.g. CYP17) |
In vitro | Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit.[Pubmed: 26041167 ]Food Chem. 2015 Dec 1;188:77-83.In the current study, we examined the effects of postharvest degreening and storage on phytochemicals in Rio Red grapefruit. |
Kinase Assay | Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells.[Pubmed: 23146034]J Pharm Pharmacol. 2012 Dec;64(12):1715-21.We previously established HepG2-GS-3A4, a cell line from hepatoblastoma with overexpression of human CYP3A4 and glutamine synthetase (GS). We further reported that these cells can be applied for screening inhibitors of CYP3A4 in vitro. |
6',7'-Dihydroxybergamottin Dilution Calculator
6',7'-Dihydroxybergamottin Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.6853 mL | 13.4264 mL | 26.8528 mL | 53.7057 mL | 67.1321 mL |
5 mM | 0.5371 mL | 2.6853 mL | 5.3706 mL | 10.7411 mL | 13.4264 mL |
10 mM | 0.2685 mL | 1.3426 mL | 2.6853 mL | 5.3706 mL | 6.7132 mL |
50 mM | 0.0537 mL | 0.2685 mL | 0.5371 mL | 1.0741 mL | 1.3426 mL |
100 mM | 0.0269 mL | 0.1343 mL | 0.2685 mL | 0.5371 mL | 0.6713 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Methyl 5-{2-[(tert-butylamino)carbothioyl]carbohydrazonoyl}-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate
Catalog No.:BCC7906
CAS No.:264233-05-8
- SB 415286
Catalog No.:BCC3651
CAS No.:264218-23-7
- Z-Orn-OH
Catalog No.:BCC2757
CAS No.:2640-58-6
- DPPA (Kg)
Catalog No.:BCC2690
CAS No.:26386-88-9
- S 25585
Catalog No.:BCC7687
CAS No.:263849-50-9
- AG 045572
Catalog No.:BCC7464
CAS No.:263847-55-8
- 3-Acetoxy-27-hydroxy-20(29)-lupen-28-oic acid methyl ester
Catalog No.:BCN1466
CAS No.:263844-80-0
- 3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester
Catalog No.:BCN1467
CAS No.:263844-79-7
- Buergerinin G
Catalog No.:BCN4659
CAS No.:263764-83-6
- EMDT oxalate
Catalog No.:BCC7888
CAS No.:263744-72-5
- PPT
Catalog No.:BCC7062
CAS No.:263717-53-9
- ESI-09
Catalog No.:BCC5504
CAS No.:263707-16-0
- Oxypeucedanin hydrate
Catalog No.:BCN2698
CAS No.:2643-85-8
- Methyl 2,2-dithienylglycolate
Catalog No.:BCC9034
CAS No.:26447-85-8
- Bz-Arg-OEt.HCl
Catalog No.:BCC2686
CAS No.:2645-08-1
- PR-619
Catalog No.:BCC3627
CAS No.:2645-32-1
- SSR 146977 hydrochloride
Catalog No.:BCC7635
CAS No.:264618-38-4
- MRS 1706
Catalog No.:BCC7120
CAS No.:264622-53-9
- MRS 1754
Catalog No.:BCC7473
CAS No.:264622-58-4
- 26-Deoxyactein
Catalog No.:BCN8076
CAS No.:264624-38-6
- Humulone
Catalog No.:BCN2682
CAS No.:26472-41-3
- Catharanthine Tartrate
Catalog No.:BCN2462
CAS No.:2648-21-5
- 6-Deoxyisojacareubin
Catalog No.:BCN7723
CAS No.:26486-92-0
- Cyclo(D-Phe-L-Pro)
Catalog No.:BCN4011
CAS No.:26488-24-4
Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit.[Pubmed:26041167]
Food Chem. 2015 Dec 1;188:77-83.
In the current study, we examined the effects of postharvest degreening and storage on phytochemicals in Rio Red grapefruit. Grapefruits were degreened with 3.5 mul/l of ethylene at 21 degrees C and 80% relative humidity for 72 h, while non-degreened fruits were used as the control. Furthermore, the grapefruits were stored at 11 degrees C for 3 weeks and then at 21 degrees C for 2 weeks. Degreening improved the peel colour of the grapefruit without affecting total soluble solids or acidity of the juice. Degreened fruits had significantly more ascorbic acid after 35 days of storage. Degreening had no significant effect on the levels of carotenoids, limonoids and flavonoids as compared to the non-degreened fruits, after 35 days of storage. However, after 7 days, degreened fruits had more limonin and flavonoids and less furocoumarin, namely 6',7'-dihydroxybergamottin. Overall, ethylene treatment had a significant effect on the phytochemical contents of Rio Red grapefruit, especially after 7 days of storage.