Oxypeucedanin hydrateCAS# 2643-85-8 |
- Oxypeucedan hydrate
Catalog No.:BCN8372
CAS No.:133164-11-1
Quality Control & MSDS
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| Cas No. | 2643-85-8 | SDF | Download SDF |
| PubChem ID | 17536 | Appearance | White powder |
| Formula | C16H16O6 | M.Wt | 304.29 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Synonyms | Aviprin; Hydroxypeucedanin hydrate; Prangol; Prangolarin hydrate | ||
| Solubility | Soluble in acetone, chloroform and methan | ||
| Chemical Name | 4-[(2R)-2,3-dihydroxy-3-methylbutoxy]furo[3,2-g]chromen-7-one | ||
| SMILES | CC(C)(C(COC1=C2C=CC(=O)OC2=CC3=C1C=CO3)O)O | ||
| Standard InChIKey | PEWFWDOPJISUOK-CYBMUJFWSA-N | ||
| Standard InChI | InChI=1S/C16H16O6/c1-16(2,19)13(17)8-21-15-9-3-4-14(18)22-12(9)7-11-10(15)5-6-20-11/h3-7,13,17,19H,8H2,1-2H3/t13-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Oxypeucedanin hydrate is an antimutagenic agent, it has antioxidant activity, and exhibits carbohydrate metabolizing enzymes inhibitory effect. |
| Targets | p21 | EGFR | Estrogen receptor | Caspase | Progestogen receptor |
| In vitro | Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.[Pubmed: 11334345]J Chromatogr B Biomed Sci Appl. 2001 Apr 5;753(2):309-14.
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| In vivo | Preliminary in vitro and in vivo evaluation of antidiabetic activity of Ducrosia anethifolia Boiss. and its linear furanocoumarins.[Pubmed: 24800231]Biomed Res Int. 2014;2014:480545.Ducrosia anethifolia is used as flavoring additive. There have been little detailed phytochemical reports on this genus and the antidiabetic activity of this plant is not yet evaluated.
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Oxypeucedanin hydrate Dilution Calculator
Oxypeucedanin hydrate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2863 mL | 16.4317 mL | 32.8634 mL | 65.7268 mL | 82.1585 mL |
| 5 mM | 0.6573 mL | 3.2863 mL | 6.5727 mL | 13.1454 mL | 16.4317 mL |
| 10 mM | 0.3286 mL | 1.6432 mL | 3.2863 mL | 6.5727 mL | 8.2158 mL |
| 50 mM | 0.0657 mL | 0.3286 mL | 0.6573 mL | 1.3145 mL | 1.6432 mL |
| 100 mM | 0.0329 mL | 0.1643 mL | 0.3286 mL | 0.6573 mL | 0.8216 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.[Pubmed:11334345]
J Chromatogr B Biomed Sci Appl. 2001 Apr 5;753(2):309-14.
A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and Oxypeucedanin hydrate, which are the main components of hot water extract of Angelica dahurica root (AE), in rat plasma. Plasma sample was simply deproteinated with perchloric acid. After centrifugation, the supernatant was injected into a column-switching HPLC system consisting of a clean-up column (Symmetry Shield RP 8, 20x3.9 mm I.D.) and analytical column (Symmetry C18, 75x4.6 mm I.D.) which were connected with a six-port switching valve. The flow-rate of the mobile phase (acetonitrile-water, 20:80) was maintained at 1 ml/min. Detection was carried out at wavelength 260 nm with a UV detector. The column temperature was maintained at 40 degrees C. The calibration curves of byak-angelicin and Oxypeucedanin hydrate were linear over the ranges 19.6 to 980 ng/ml (r2>0.997). The accuracy of these analytes was less than 4.4%. The intra- and inter-day relative standard deviations of byak-angelicin and Oxypeucedanin hydrate were within 12.0% and 12.7%, respectively. The present method was applied for the analysis of plasma concentration from rats after administration of AE.
Preliminary in vitro and in vivo evaluation of antidiabetic activity of Ducrosia anethifolia Boiss. and its linear furanocoumarins.[Pubmed:24800231]
Biomed Res Int. 2014;2014:480545.
Aim. Ducrosia anethifolia is used as flavoring additive. There have been little detailed phytochemical reports on this genus and the antidiabetic activity of this plant is not yet evaluated. Method. Structure of compounds was deduced by spectroscopic analyses. Preliminary in vitro evaluation of the antidiabetic activity of crude extract and its furanocoumarins was carried out ( alpha -amylase, alpha -glucosidase, and beta -galactosidase). The in vivo activity was investigated by measuring some oxidative stress markers. Biomarkers of liver injury and kidney were also determined. Results. Eight linear furanocoumarins, psoralen, 5-methoxypsoralen, 8-methoxypsoralen, imperatorin, isooxypeucedanin, pabulenol, oxypeucedanin methanolate, Oxypeucedanin hydrate, and 3-O-glucopyranosyl- beta -sitosterol, were isolated. All compounds were reported for the first time from the genus Ducrosia except pabulenol. The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. The antioxidant markers, glucolytic, and gluconeogenic enzymes were significantly ameliorated and the elevated level of kidney biomarkers in the diabetic groups was restored. The compounds showed inhibitory activity in a concentration dependant manner. Imperatorin and 5-methoxypsoralen showed the most potent inhibiting power. Conclusion. D. anethifolia extract showed hypoglycemic, hypolipidemic, and antioxidant effect as well as ameliorating kidney function. This extract and some linear furanocoumarins exhibited carbohydrate metabolizing enzymes inhibitory effect.
