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Catharanthine Tartrate

CAS# 2648-21-5

Catharanthine Tartrate

2D Structure

Catalog No. BCN2462----Order now to get a substantial discount!

Product Name & Size Price Stock
Catharanthine Tartrate: 5mg $35 In Stock
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Quality Control of Catharanthine Tartrate

Quality Control & MSDS

3D structure

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Catharanthine Tartrate

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Chemical Properties of Catharanthine Tartrate

Cas No. 2648-21-5 SDF Download SDF
PubChem ID 24721367 Appearance Powder
Formula C25H30N2O8 M.Wt 486.40
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2,3-dihydroxybutanedioic acid;methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8,16-pentaene-1-carboxylate
SMILES CCC1=CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O
Standard InChIKey JYBKPXVXYJDIFX-GYMDHWDQSA-N
Standard InChI InChI=1S/C21H24N2O2.C4H6O6/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18;5-1(3(7)8)2(6)4(9)10/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t13-,19+,21-;/m0./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Catharanthine Tartrate

The herbs of Catharanthus roseus (L.) G.Don

Biological Activity of Catharanthine Tartrate

DescriptionCatharanthine Tartrate is an anti-tumor drug. Catharanthine Tartrate binds with DNA in a mode of groove binding, Se(Ⅳ)can inhibit the binding of Catharanthine Tartrate and DNA.
TargetsDNA/RNA Synthesis
In vitro

Synthesizing method of vinorelbine tartrate[Reference: WebLink]

CN20071097400


METHODS AND RESULTS:
The invention discloses a synthesis method of vinorelbine bitartrate which is characterized in that the method includes following steps: (1) having the Catharanthine Tartrate and vindoline as initial material, reacting with ferric trichloride and hydrochloric acid (2) reacting the above product with the sldium borohydride to get dehydrated vinblastine (3) ring-opening the dehydrated vinblastine by trifluoroacetic anhydride and rearranging to obtain the vinorelbine bitartrate.
CONCLUSIONS:
The method has a low production cost and a high yield and has a good application future.

Protocol of Catharanthine Tartrate

Structure Identification
《Journal of Huazhong Normal University(Natural Sciences)》 2011-04

Study on the interaction between catharanthine tartrate and DNA by spectrometric method[Reference: WebLink]


METHODS AND RESULTS:
The interaction of Catharanthine Tartrate and DNA was studied using UV spectrometry,fluorescence spectrometry and fluorescent probe.The results showed that the fluorescence intensity of Catharanthine Tartrate was quenched in the presence of DNA,and this mechanism was judged as static quenching.The binding constant K at 25℃ and 40℃ were calculated as 5.38×104 and 5.85×102,and the binding sites number n as 1.405 and 0.8306.According to the binding constant K at 25℃ and 40℃,the thermodynamic parameters of the reaction of Catharanthine Tartrate and DNA were calculated as follows: ΔHm=-233.77 kJ·mol-1,ΔGm(298 K)=-27.0 kJ·mol-1,ΔSm(298 K)=-693.8 J·K-1·mol-1,and the main binding force between Catharanthine Tartrate and DNA is hydrogen bonding or van der Waals force according to thermodynamic parameters.
CONCLUSIONS:
The UV spectrometry test showed that as the DNA concentration increased,the blue shift of the absorbance peak occured and the absorbance decreased significantly,the results of fluorescence probe test further proved that Catharanthine Tartrate binds with DNA in a mode of groove binding.

《Journal of Hainan Normal University(Natural Science)》 2014-03

Study on the Effect of Se(Ⅳ) on the Interaction Between Catharanthine Tartrate and DNA[Reference: WebLink]


METHODS AND RESULTS:
The effect of Se(Ⅳ)on the interaction between Catharanthine Tartrate and DNA was studied by fluorescence spectrometry, UV spectroscopy and viscosity method. The results showed that the addition of Se(Ⅳ)changed the main binding force of Catharanthine Tartrate and DNA from hydrogen bond and van der Waals force into electrostatic force, and the binding mode from groove binding into electrostatic binding.
CONCLUSIONS:
The change of binding constant and the UV spectroscopy results showed that Se(Ⅳ)can inhibit the binding of Catharanthine Tartrate and DNA.

Catharanthine Tartrate Dilution Calculator

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Catharanthine Tartrate Molarity Calculator

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Preparing Stock Solutions of Catharanthine Tartrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0559 mL 10.2796 mL 20.5592 mL 41.1184 mL 51.398 mL
5 mM 0.4112 mL 2.0559 mL 4.1118 mL 8.2237 mL 10.2796 mL
10 mM 0.2056 mL 1.028 mL 2.0559 mL 4.1118 mL 5.1398 mL
50 mM 0.0411 mL 0.2056 mL 0.4112 mL 0.8224 mL 1.028 mL
100 mM 0.0206 mL 0.1028 mL 0.2056 mL 0.4112 mL 0.514 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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