MEK
MEK, also known as Mitogen-activated protein kinase kinase and MAP2K, is a kinase enzyme that phosphorylates mitogen activated protein kinases (MAPKs), ERK, p38 and JNK. Seven MEK subtypes have been identified, all mediate cellular responses to different growth signals.
Products for MEK
- Cat.No. Product Name Information/Activity
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BCN6291
Arctigenin
Arctigenin is a lignan found in certain plants of the Asteraceae; it has shown antiviral and anticancer effects in glass; it is the aglycone of arctiin.
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BCC5773
10Z-Hymenialdisine
82005-12-7
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BCC1277
PD0325901
PD0325901 is a selective and cell permeable MEK inhibitor with an IC50 of 0.33 nM.
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BCC1112
PD184352 (CI-1040)
CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1.
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BCC7428
PD 198306
Selective inhibitor of MEK1/2
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BCC6300
PD 334581
548756-68-9
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BCC1098
PD98059
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits autophagy.
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BCC1123
SL-327
SL327 inhibits MEK1 and MEK2, with IC50 values of 180 nM and 220 nM, respectively.
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BCC7200
U0124
108923-79-1
