Histamine H4 Receptor
Histamine H4 receptors are Gα i/o-protein-coupled receptors, first cloned in 2000. H4 receptors are expressed at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and peripheral hematopoietic cells, including eosinophils and T lymphocytes.
Products for Histamine H4 Receptor
- Cat.No. Product Name Information/Activity
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BCC6781
Clobenpropit dihydrobromide
Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC50 of 8.07 for histamine H3LR. Clobenpropit dihydrobromide acts as partial agonist at histamine H4 receptors (Ki 13 nM). Clobenpropit dihydrobromide also binds to serotonin 5-HT3 receptors (Ki 7.4 nM) and α2A/α2C adrenoceptors (Ki 17.4/7.8 nM). Clobenpropit dihydrobromide increases apoptosis.
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BCC4530
Histamine 2HCl
Histamine dihydrochloride is an endogenous metabolite.
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BCC6768
Imetit dihydrobromide
Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).
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BCC6853
Immepip dihydrobromide
164391-47-3
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BCC7337
4-Methylhistamine dihydrochloride
Selective, high affinity H<sub>4</sub> agonist
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BCC6285
VUF 10460
VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.
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BCC7384
VUF 8430 dihydrobromide
100130-32-3
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BCC7772
A 943931 dihydrochloride
Potent and selective H<sub>4</sub> antagonist
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BCC7732
A 987306
Potent and selective H<sub>4</sub> receptor antagonist
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BCC7362
JNJ 10191584 maleate
869497-75-6
