beta-catenin
β-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading β -catenin, which includes GSK-3.
Products for beta-catenin
- Cat.No. Product Name Information/Activity
-
BCC7131
Calphostin C
121263-19-2
-
BCC6199
Cardionogen 1
577696-37-8
-
BCC6258
CCT 031374 hydrobromide
1219184-91-4
-
BCC1573
FH535
FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.
-
BCC3632
ICG 001
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
-
BCC5401
iCRT 14
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase.
-
BCC5602
IWP 4
IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM.
-
BCC5102
IWR-1-endo
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
-
BCC7823
exo-IWR 1
1127442-87-8
-
BCC6251
JW 67
442644-28-2
