Multidrug Transporter
ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.
Products for Multidrug Transporter
- Cat.No. Product Name Information/Activity
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BCC7882
CP 100356 hydrochloride
142715-48-8
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BCC1547
Elacridar hydrochloride
Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
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BCC7719
Estropipate
Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis.
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BCC7507
Fumitremorgin C
Fumitremorgin C is a potent and selective ABCG2/BRCP inhibitor.
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BCC1684
Ko 143
Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters.
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BCC7874
KS 176
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
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BCC7334
MK 571
MRP1 inhibitor; also CysLT<sub>1</sub> (LTD<sub>4</sub>) inverse agonist
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BCC4832
Probenecid
Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.
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BCC2027
Valspodar
Valspodar is a selective P-glycoprotein inhibitor that has been used as an experimental cancer treatment and chemosensitizer.
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BCC2307
Pyrimethamine
Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).
