Glutamate (Metabotropic) Group II Receptor
Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.
Products for Glutamate (Metabotropic) Group II Receptor
- Cat.No. Product Name Information/Activity
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BCC6590
(1S,3R)-ACPD
111900-32-4
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BCC6566
cis-ACPD
477331-06-9
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BCC6567
(±)-trans-ACPD
trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.
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BCC6969
(2R,4R)-APDC
(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects.
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BCC6607
(S)-3-Carboxy-4-hydroxyphenylglycine
55136-48-6
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BCC6600
(S)-4-Carboxy-3-hydroxyphenylglycine
85148-82-9
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BCC6603
(S)-4-Carboxyphenylglycine
134052-73-6
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BCC6609
L-CCG-l
117857-93-9
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BCC5691
DCG IV
DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1/5R=389/630 μM) and III receptors (IC50: mGlu4/6/7/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.
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BCC7614
LY 354740
Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively.
