STIM-Orai Channel
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.
Products for STIM-Orai Channel
- Cat.No. Product Name Information/Activity
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BCC6644
ML 9 hydrochloride
ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation.
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BCC6953
SKF 96365 hydrochloride
SKF-96365 hydrochloride is a non-selective TRP Channel blocker.
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BCC7817
YM 58483
YM-58483 is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals.
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BCC6978
2-APB
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3).
