Ubiquitin E2 Conjugating Enzyme
The ubiquitin (Ub)/Ub-like (Ubl) conjugating enzymes are a conserved family of ligases which mediate the conjugation of Ub and Ubl proteins to target substrates. There have been 35 E2 enzymes identified in the human genome to date.
Products for Ubiquitin E2 Conjugating Enzyme
- Cat.No. Product Name Information/Activity
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BCC2244
Bay 11-7821(BAY 11-7082)
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.
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BCC4200
CC0651
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently (IC50=1.72 μM) inhibits the ubiquitination of p27Kip1, as confirmed by dose-response analysis.
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BCC4000
NSC697923
Selective UBE2N inhibitor,NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.
