Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 19

  1. Cat.No. Product Name Information/Activity
  2. BCC7907 VU 0357017 hydrochloride VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15). VU 0357017 hydrochloride chemical structure
  3. BCC6628 Arecaidine propargyl ester tosylate 147202-94-6 Arecaidine propargyl ester tosylate chemical structure
  4. BCC6939 AF-DX 116 Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC50 values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively. AF-DX 116 chemical structure
  5. BCC7024 AF-DX 384 118290-26-9 AF-DX 384 chemical structure
  6. BCC7314 AQ-RA 741 Selective, high affinity M<sub>2</sub> antagonist AQ-RA 741 chemical structure
  7. BCC7061 (S)-(+)-Dimethindene maleate 136152-65-3 (S)-(+)-Dimethindene maleate chemical structure
  8. BCC6661 4-DAMP 1952-15-4 4-DAMP chemical structure
  9. BCC7263 DAU 5884 hydrochloride 131780-48-8 DAU 5884 hydrochloride chemical structure
  10. BCC7389 J 104129 fumarate 257603-40-0 J 104129 fumarate chemical structure
  11. BCC7418 Zamifenacin fumarate Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome. Zamifenacin fumarate chemical structure

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