Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 20

  1. Cat.No. Product Name Information/Activity
  2. BCC7145 PD 102807 23062-91-1 PD 102807 chemical structure
  3. BCC4574 Tropicamide Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist . Tropicamide chemical structure
  4. BCC4053 VU0152100 VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM. VU0152100 chemical structure
  5. BCC7729 VU 0238429 VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM. VU 0238429 chemical structure
  6. BCC6164 VU 0365114 VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM. VU 0365114 chemical structure
  7. BCC7705 3-Bromocytisine 3-Bromocytisine (3-Br-cytisine) is a potent nACh receptors agonist, with IC50s are 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7-nACh, respectively. 3-Bromocytisine (3-Br-cytisine) shows different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs with EC50s are 8 and 50 nM, respectively. 3-Bromocytisine chemical structure
  8. BCC7099 5-Iodo-A-85380 dihydrochloride 1217837-17-6 5-Iodo-A-85380 dihydrochloride chemical structure
  9. BCC7102 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative 213766-21-3 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative chemical structure
  10. BCC3821 Nicotine Difartrate 65-31-6 Nicotine Difartrate chemical structure
  11. BCC6118 3-pyr-Cytisine 948027-43-8 3-pyr-Cytisine chemical structure

Items 191 to 200 of 752 total