Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research

  1. Cat.No. Product Name Information/Activity
  2. BCC2391 ARRY 520 trifluoroacetate Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation,ARRY-520 is a synthetic kinesin spindle protein (<b>KSP</b>) inhibitor with <b>IC<sub>50</sub></b> of 6 nM. ARRY 520 trifluoroacetate chemical structure
  3. BCC2394 Bax inhibitor peptide V5 Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment. Bax inhibitor peptide V5 chemical structure
  4. BCC2395 Bax inhibitor peptide, negative control Negative control peptide for Bax inhibitor peptide V5 Bax inhibitor peptide, negative control chemical structure
  5. BCN2318 Gambogic acid Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM. Gambogic acid chemical structure
  6. BCC3593 HA14-1 HA14-1 is a Bcl-2/Bcl-XL antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC50 of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function. HA14-1 chemical structure
  7. BCC4098 Marinopyrrole A Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM). Marinopyrrole A chemical structure
  8. BCC2256 Methylprednisolone Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone chemical structure
  9. BCC2257 TW-37 TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively. TW-37 chemical structure
  10. BCC1397 BAM7 BAM7 is a direct and selective activator of proapoptotic BAX with an IC50 of 3.3 μM. BAM7 chemical structure
  11. BCC1375 Gossypolone Downregulates Bcl-2 and Mcl-1; pro-apoptotic Gossypolone chemical structure

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