Cystic Fibrosis Research
Cystic fibrosis (CF) is a common inherited disease that mostly affects the lungs and airways of a sufferer. One of the main pathological characteristics of CF is the failure of airway defence against bacterial infection, leading to frequent chest infection and progressive lung damage.
Cystic Fibrosis Research Products Targets
Products for Cystic Fibrosis Research - Page 3
- Cat.No. Product Name Information/Activity
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BCC6220
T16Ainh - A01
T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).
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BCC7391
Talniflumate
66898-62-2
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BCC7578
KM 11060
KM11060 is a novel corrector of the F508del-CFTR trafficking defect.
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BCC7820
PG 01
PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K
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BCC7886
BTZO 1
BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.
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BCC6816
Chicago Sky Blue 6B
2610-05-1
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BCC6161
(±)-CPSI 1306
(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).
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BCC5914
ER 27319 maleate
1204480-26-1
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BCC2096
Gabexate mesylate
Gabexate mesylate is a Factor X inhibitor; serine protease inhibitor .
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BCC5203
VGX-1027
VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.
