Cystic Fibrosis Research
Cystic fibrosis (CF) is a common inherited disease that mostly affects the lungs and airways of a sufferer. One of the main pathological characteristics of CF is the failure of airway defence against bacterial infection, leading to frequent chest infection and progressive lung damage.
Cystic Fibrosis Research Products Targets
Products for Cystic Fibrosis Research - Page 9
- Cat.No. Product Name Information/Activity
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BCC6717
17-ODYA
Alkynyl Stearic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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BCC7882
CP 100356 hydrochloride
142715-48-8
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BCC1547
Elacridar hydrochloride
Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
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BCC7719
Estropipate
Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis.
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BCC7507
Fumitremorgin C
Fumitremorgin C is a potent and selective ABCG2/BRCP inhibitor.
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BCC1684
Ko 143
Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters.
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BCC7874
KS 176
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
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BCC4832
Probenecid
Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.
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BCC2027
Valspodar
Valspodar is a selective P-glycoprotein inhibitor that has been used as an experimental cancer treatment and chemosensitizer.
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BCC2307
Pyrimethamine
Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).
