Sirtuin

Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

Products for Sirtuin

  1. Cat.No. Product Name Information
  2. BCN5607 Resveratrol Cyclooxygenase inhibitor
  3. BCC1950 SRT2104 (GSK2245840)
  4. BCC2222 SRT1720 HClSIRT1 activator
  5. BCC2223 EX 527 (SEN0014196)Selective SIRT1 inhibitor
  6. BCC2224 SirtinolSelective sirtuin family deacetylase inhibitor
  7. BCC3652 SplitomicinSir2p inhibitor
  8. BCC3667 Tenovin-6SIRT inhibitor and p53 activator
  9. BCC5146 InauhzinSIRT1 inhibitor
  10. BCC5426 AK-7Selective SIRT2 inhibitor; brain penetrant
  11. BCC5594 EX-527 S-enantiomer
  12. BCC5595 EX-527 R-enantiomer
  13. BCC6482 Triacetyl ResveratrolCell-permeable resveratrol prodrug

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