Sirtuin
Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.
Products for Sirtuin
- Cat.No. Product Name Information
- BCN5607 Resveratrol Cyclooxygenase inhibitor
- BCC1950 SRT2104 (GSK2245840)
- BCC2222 SRT1720 HClSIRT1 activator
- BCC2223 EX 527 (SEN0014196)Selective SIRT1 inhibitor
- BCC2224 SirtinolSelective sirtuin family deacetylase inhibitor
- BCC3652 SplitomicinSir2p inhibitor
- BCC3667 Tenovin-6SIRT inhibitor and p53 activator
- BCC5146 InauhzinSIRT1 inhibitor
- BCC5426 AK-7Selective SIRT2 inhibitor; brain penetrant
- BCC5594 EX-527 S-enantiomer
- BCC5595 EX-527 R-enantiomer
- BCC6482 Triacetyl ResveratrolCell-permeable resveratrol prodrug