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EX-527 S-enantiomer

CAS# 848193-68-0

EX-527 S-enantiomer

Catalog No. BCC5594----Order now to get a substantial discount!

Product Name & Size Price Stock
EX-527 S-enantiomer: 5mg $368 In Stock
EX-527 S-enantiomer: 10mg Please Inquire In Stock
EX-527 S-enantiomer: 20mg Please Inquire Please Inquire
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Quality Control of EX-527 S-enantiomer

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Chemical structure

EX-527 S-enantiomer

3D structure

Chemical Properties of EX-527 S-enantiomer

Cas No. 848193-68-0 SDF Download SDF
PubChem ID 707029 Appearance Powder
Formula C13H13ClN2O M.Wt 248.71
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Selisistat S-enantiomer
Solubility DMSO : ≥ 100 mg/mL (402.07 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
SMILES C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
Standard InChIKey FUZYTVDVLBBXDL-VIFPVBQESA-N
Standard InChI InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)/t9-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

EX-527 S-enantiomer Dilution Calculator

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EX-527 S-enantiomer Molarity Calculator

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Preparing Stock Solutions of EX-527 S-enantiomer

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.0207 mL 20.1037 mL 40.2075 mL 80.4149 mL 100.5187 mL
5 mM 0.8041 mL 4.0207 mL 8.0415 mL 16.083 mL 20.1037 mL
10 mM 0.4021 mL 2.0104 mL 4.0207 mL 8.0415 mL 10.0519 mL
50 mM 0.0804 mL 0.4021 mL 0.8041 mL 1.6083 mL 2.0104 mL
100 mM 0.0402 mL 0.201 mL 0.4021 mL 0.8041 mL 1.0052 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on EX-527 S-enantiomer

EX-527 S-enantiomer is the S-enantiomer of EX-527, with an IC50 of 123 nM for SIRT1. EX-527 S-enantiomer is much more potent than EX-527 R-enantiomer.

References:
[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

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Description

Selisistat S-enantiomer (EX-527 S-enantiomer) is the S-enantiomer of Selisistat, with an IC50 of 123 nM for SIRT1. Selisistat S-enantiomer is much more potent than Selisistat R-enantiomer.

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