VasicinoloneCAS# 84847-50-7 |
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| Cas No. | 84847-50-7 | SDF | Download SDF |
| PubChem ID | 158720 | Appearance | Powder |
| Formula | C11H10N2O3 | M.Wt | 218.2 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3S)-3,7-dihydroxy-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one | ||
| SMILES | C1CN2C(=NC3=C(C2=O)C=C(C=C3)O)C1O | ||
| Standard InChIKey | MKNHUAILAQZBTQ-VIFPVBQESA-N | ||
| Standard InChI | InChI=1S/C11H10N2O3/c14-6-1-2-8-7(5-6)11(16)13-4-3-9(15)10(13)12-8/h1-2,5,9,14-15H,3-4H2/t9-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The leaves of Adhatoda vasica
| Description | 1. Vasicinolone has anti-inflammatory activity. 2. Vasicinolone has antimicrobial activity. |
| Targets | Antifection | Immunology & Inflammation related |
Vasicinolone Dilution Calculator
Vasicinolone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.583 mL | 22.9148 mL | 45.8295 mL | 91.659 mL | 114.5738 mL |
| 5 mM | 0.9166 mL | 4.583 mL | 9.1659 mL | 18.3318 mL | 22.9148 mL |
| 10 mM | 0.4583 mL | 2.2915 mL | 4.583 mL | 9.1659 mL | 11.4574 mL |
| 50 mM | 0.0917 mL | 0.4583 mL | 0.9166 mL | 1.8332 mL | 2.2915 mL |
| 100 mM | 0.0458 mL | 0.2291 mL | 0.4583 mL | 0.9166 mL | 1.1457 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anti-inflammatory and antimicrobial properties of pyrroloquinazoline alkaloids from Adhatoda vasica Nees.[Pubmed:23357363]
Phytomedicine. 2013 Mar 15;20(5):441-5.
Adhatoda vasica Nees, Acanthaceae, is well known plant in Ayurveda and Unani medicine. The purpose of this study was to characterize the most bioactive phytochemicals viz., vasicine, vasicinone, vasicine acetate, 2-acetyl benzyl amine, Vasicinolone present in the chloroform fraction having anti-inflammatory and antimicrobial activities. The anti-inflammatory activity was tested by using carrageenan and CFA-model induced paw oedema. The antimicrobial activity of isolated compounds was assessed by using the microdilution method. The observed results revealed that vasicine showed most potent anti-inflammatory effects (59.51%) at the dose of 20.0mg/kg at 6h after carrageenan injection and maximum inhibition rate was observed of vasicinone (63.94%) at the dose of 10.0mg/kg at 4 days after CFA injection. The strong antibacterial activity was exhibited by vasicine at 20mug/ml dose against E. coli and also demonstrated maximum antifungal activity against C. albicans at the dose of >55mug/ml. All the five alkaloids demonstrated significant anti-inflammatory and antimicrobial activities.
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